Can i take mirtazipine + sertraline together
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Hi been on sert 50mg for 9 wks + only had a few gd days here + there of normality.Doc reckons i shld come off as ssri's aint for me(fluoxetine made me "crazy" so came off after 3 days).Any advice/experience for tapering off sert + at what point can i take mirt with sert ? mirt is an NaSSA which is a diff class of AD than the ssri sert so in theory they can be taken together but do not know at what point,
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sleepless_again plainden
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plainden sleepless_again
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dinky_dee sleepless_again
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plainden dinky_dee
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sleepless_again dinky_dee
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dinky_dee plainden
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plainden dinky_dee
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dinky_dee plainden
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tony15730 plainden
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Firstly Mirtazipine works by Antagonising (ie, Blocking) the HT2 serotonin receptors. This leads to more serotonine being available for the HT1 receptor, which is where you want it for its ad effect. When combined with an ssri you get even more serotonine to the HT1 receptor and so both work together increase the anti depressant effect.
Secondly adding Mirt to an ssri reduces the side effects of the ssri (nausea, sexual side effects) you get from the ssri. This is becuase a lot of the side effects from ssri's are caused by to much serotonine hitting the HT2 recpetors. Mirtazapine works by blocking the HT 2 receptor so less serontine will affect them. Mirt can also me added to a SNRI for the same reasons.
Mirt is not without side effects though. The two main ones are sedation and apitite stimulant. Some users find it wors than others so see how you get on.
What dose opf mirt are you on? I have read its side effects max out at only 15mg and higher doses than that do not result in worse side affects and some users report less side effects on doses of 30mg and up so have a good read in the forums about that.
Have a good internet search for ssri + mirt and you will find alot of info.
dinky_dee plainden
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tony15730 dinky_dee
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I assume you mean the protein L-Tryptophane and not 5-HTP which is more easily converted to serotonin???
dinky_dee tony15730
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tony15730 dinky_dee
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The difference is if the body thinks there is too much serotonine it wont convert any more L-Tryptophan to 5-HTP but it will continue to convert 5-HTP to serotonin.
That said 95% of 5-HTP taken orally will not reach the brain and will only increase serotonine in the body. Hence it can cause nausea for some people.
Balbie plainden
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what would happen if you take both mirtazapine and sertraline together at nighttime?