Can prolonged use of Combodart for BPH make it difficult to detect cancer in PSA tests?

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Hi, About 5 years ago (aged 49), I was referred for further tests as a result of a routine blood test revealing a PSA level of 9.5 The standard 10 biopsies were clear, so I was referred for a further 25. Of this further 25, one came back as 'A Typical'. The specialist explained that this basically meant that the laboratory could not be sure and that it might indicate a pre-cancerous condition, or perhaps that the biopsy was taken from an area near a cancerous growth. At that point I was introduced to a Macmillan nurse and advised to consider a TURP procedure. I decided to pay privately for the template biopsy procedure, where a further 65 biopsies were taken. To the surprise of the specialist, this came back clear and he advised me that with 99% certainty my diagnosis was BHP. As a result I've been on Combodart ever since. My only follow up is an annual PSA test which has consistently been 3.8 The question I forgot to ask was whether the BPH drug could affect the PSA reading, making it impossible to tell whether there was or is cancer present?

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    Well, spoke to the GP. Apparently they double the PSA reading to take into account the effect of the Combodart and really just look for sizeable changes. So, as long as my annual level doesn't change more than about 0.5, I should be OK (although, as we all know there really isn't any completely reliable prostate cancer tests).

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