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Can you still have histamine intolerance if you go back on mirtazapine?

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Dbs1
Dbs1

Hi, I never actually stopped Mirtazapine, but I had to take an antibiotic Rifampin for latent TB that reduces and clears Mirtazapine faster. My first meal after my first dose of Rifampin I got tingling in my lips and face while eating what I later learned was a high histamine meal. That continued a number of times with meals that were high histamine, so I have been eating low histamine (the same three meals every day) for 6 months. I've been off Rifampin for two months, I could feel the Mirtazapine sleep effect come back after two weeks so a couple weeks ago I tried some higher histamine foods again including avocado and the next morning while eating (actually one of my safe meals) broke out into a rash on my face neck and hands. So I guess it still isn't safe. I've seen two allergists and think I am on my own on how to handle this. thanks.

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1 Reply

  • Mirtazapain
    Mirtazapain Dbs1

    Posted

    Hi,

    Your question is really interesting. I've had the opposite effect. Mirtazapine is an antihistamine, especially at low doses, which is why it seems to be so sedating. Kind of like Benadryl.

    When I went on mirtazapine 5.5 years ago (22.5 mg) for major depression one of the intriguing side benefits was to that it cleared up a rash that I'd had on my body for 20 years.

    I've slowly tapered down to 7.5 mg over the last few years, and I notice itching when my dose lowers. I've often wondered if that's because I am getting less of an antihistamine effect.

    I am sorry you are struggling with this.

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