Could Paxil be causing extreme muscle fatigue?

Posted , 3 users are following.

Hello, I've been on Paxil for just over 15 yrs now and for the last year and a half have developed extreme muscle fatigue and pain. It's to the point where I am having trouble with my daily routines. I can not walk through a store and shop without feeling like I could collapse because my muscles are so exhausted. This started as episodes in my thigh muscles and spread to be episodes in the muscles all over to even the muscles in my face. When I speak any louder than my normal voice my vocal chords get exhausted and my voice gets weak and raspy. When I'm eating something that takes chewing the muscles in my jaw get fatigued. I have no trouble swallowing thank God. The episodes at the beginning of this were infrequent and didn't last long, maybe 15 minutes but progressed to happening to each muscle that was used every time it was used and taking much longer to recover.

After seeing a neurologist and having all different tests done for jyst about every muscle disease, he has come to the conclusion it is the Paxil that is causing all of this. He told me neurologists don't like Paxil and that I was on too high of a dose, 60mg a day. He told me to cut down to 20mg a day and prescribed Zoloft to start in 2 weeks or sooner if the withdrawal effects get too bad.

Big mistake taking that drastic drop in dosage advice! The withdrawal effects have been horrible especially on top of how I've been feeling with the extreme muscle fatigue in the first place.

Here is a list of my withdrawal symptoms: electric brain squeezing, flu like symptoms which include sweating one minute to freezing the next (I'm on day 17 of lower dose and still feeling hot/cold throughout the day), muscle pain like you get with the flu, stomach pain with semi loose bowel movements, big time anxiety episodes, irritable and overly emotional, trouble sleeping throughout the night and when sleepy because of this during the day I constantly wake up in a panic feeling like I'm on the verge of a severe anxiety attack.

I contacted my regular physician to talk about these withdrawal symptoms and what would help ease them and she told me the drop in dosage was too fast and I should not be taking the Zoloft the same time I'm taking the Paxil even at the lower dose. Yikes, it's hard to know what to do when the two Drs. you are relying on to help you contradict each others medical advice.

At this time I am alternating 20mg and 10mg and not taking the Zoloft until I stop the Paxil. I plan on calling my regular physician tomorrow to find out when to next lower the dose of the Paxil so that I can finally be off of it and find out if it is what has been causing the worsening, all over extreme muscle fatigue.

My advice to anyone about to start taking Paxil, don't. Ask your physician for an anxiety medication with less severe withdrawal symptoms. Reading these symptoms on a list is nothing compared to actually experiencing them in real life. I will try a low dose of Zoloft and look into cognitive behavior therapy to help me deal with my anxiety.

If anyone else has had these extreme muscle fatigue episodes while on Paxil please let me know. I'd really like to know if my neurologist is on the right track, I have had extremely low quality of life for the past year and am afraid of it becoming a permanent situation.

Thanks for reading!


0 likes, 1 reply


1 Reply

  • Posted

    I took paxil on and off for 17 years due to specific things which caused panic attacks during a long drawn out menopause. I had to go off of it 3 times due to hi liver enzymes. I could never tolerate more than 15 mg. 2 years ago, I realized it no longer helped with my specific triggers & it was increased to 25 mg ER. A year ago I developed full body tremors and muscle cramps. The Dr. would not assist so I went cold turkey. After about 3 months I was fine and took no other meds. I had some traumatic events this fall and they put me on zoloft which is the same type of serotonin drug. After a month of tremors, agitation and sleeplessness, a pharmacist diagnosed serotonin syndrome which can damage tour kidneys or kill you! They put me on highly addictive clonazapan to withdraw and stop the tremors!! It's been 6 weeks now and maybe once or twice a week I have to take a low dose of the clonazapan. I want to improve and quit taking that crap!

    Report Reply

Report as inappropriate

Thanks for your help!

We want the forums to be a useful resource for our users but it is important to remember that the forums are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the forums is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.