Creatinine rise and ace inhibitors

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The good news is that after a few weeks of ace inhibitors my blood pressure and printeinura have dropped significantly.

The bad news is my creatinine has increased quite a lot in just a few weeks which is concerning me. I understand this often happens when starting ace inhibitors. Has anyone else experienced this?

Thanks.

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  • Posted

    Joel, my creatine increased to 123 immediately on starting an Angiotensin Receptor Blocker for high B.P.   Renal Consultant isn’t concerned about this, saying it is something they expect to see with certain B.P. medications.   
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    • Posted

      Thanks mrs S. My renal consultant was the same. I guess it's just hard when your creatinine is already high (much higher than yours) to see it go up quickly!

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    • Posted

      Does your nephrologist think you creatinine will settle back down after you've been on the BP meds for awhile? I gather that the thinking is that over time the BP meds will better protect your kidneys even with this increase in creatinine rather than the ongoing deterioration that would occur without the BP medication--but is that assumption accurate?

      I actually don't present high BP; rather, mine is often too low. I'm thinking that if you and I could average our BP it might be just about perfect🐶

      Let us know how this progresses.

      Marj

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    • Posted

      He (nephrologist) was not that concerned. When I googled it on the internet it was pretty much along the lines you mentioned, in that many patients experience a rise in creatinine due to starting ACE but it is still better for them in the long run. I know my blood pressure has gone from 180+ down to 110, and my proteinuria from around 4-5 to under 1, so it is helping in that respect. 

      But it's hard to accept further loss of GFR when it is already so low!

      Thanks again Marj.

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    • Posted

      Absolutely with regard to the additional loss of function. I remember hoping that there would be improvement when they got my treatment plan set--I just had to do what I was told. But, overall, that certainly has not been the case for me either. Actually I've been working with my nephrologist for 4.5 years now. My creatinine has deteriorated from1.2 (close to 50% function) to as poor as 4.6. There had been small gains during that time, i.e., from 3.2 to 2.0 where it held steady for close to two years--until I got walking pneumonia last winter. Then it plummeted to 4.6. Again there was some improvement after to 3.6. It has been steady at 3.6 for close to a year. My nephrologist had said that was my new baseline now. 

      That's why it was such a surprise to see another gain with it coming in at 2.8 recently. I'm hoping my nephrologist will be able to stabilize them at this level. (Of course, I would love to see them pull back to 2.0 again but have no idea whether that is a possibility.) At this point I'm just thrilled to be back into low Stage IV rather than Stage V.

      My nephrologist had referred me to a university specialist last August. That nephrologist focused solely on me low BP. He clearly stated that he thought that my BP was low enough to be causing me more problems--that it was inhibiting my renal function. At that time I was taking a very low dose of BP medication. He pulled me off it. My BP has been in very good range since I discontinued that medication. But my Nov labs were the first labs that showed any real improvement in renal function.

      So I'm still trying to learn more about all of this. For me, I'm just hoping for stability with them functioning in Stage IV range. I'm actually feeling fairly good with my BP in this range and a change to my anemia treatment plan. So, I'm hoping it may be a few more years before I have to prepare for dialysis.

      Nevertheless, I'm ready to start PD dialysis when the time comes. But, of course, I'd like to postpone that inevitability as long as possible.

      Anyway, I'd appreciate hearing what you learn about BP levels and renal function. While mine is running low rather than high,  I've been lead to believe that it is equally problematic and causes fairly similar problems; although, I'm sure the treatment protocol is different across the two BP issues.

      Marj

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