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Hi -- I'm in my late 60s and have been on antidepressants since I was 30 (stopped when I was pregnant, but otherwise almost continuously). Most recently was on 20mg citalopram for 3 years. It was never as good as my previous antidepressants -- imipramine and venlafaxine, but I had to stop those because of gastric side effects and raised liver enzymes. The citalopram seemed to stop working a couple of months ago -- was getting bad anxiety and my mood was low. After a middle-of-the-night panic attack (never happened to me before) and a mood crash, my GP switched me to 50mg sertraline, plus zopiclone to help me sleep and propanolol for anxiety. That was a month ago. A week later, a different doctor upped the sertraline to 100mg, and then he upped it to 150 a week and a half after that. He has also put me on 150mg pregabalin instead of the propanolol. I started getting palpitations after upping the sertraline, so after a few days, he said it would be ok to go back down to 100. That was 4 days ago.
So I have been on sertraline at varying doses a total of 4 weeks, and I still feel horrible. The initial crippling anxiety, which I had never experienced with such intensity, has gone. But I have no appetite, can't sleep without zopiclone, and my mood is in a black hole. It has never taken so long for an antidepressant to kick in before, and I am thinking that the sertraline is totally ineffective (although every now and then I have an afternoon and evening when I feel a bit better). I'd really be grateful to hear from anyone else who has experienced anything similar -- when you switch antidepressants, how long do you give the new one before you decide it's not working? Thanks for your help!
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