Disturbed sleep on Venlafaxine and Mirtazapine

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I have been on Mirtazapine 30 and Venlafaxine together for 6 weeks now. My Venlafaxine got increased to 225 a week ago and I have been having horrendous sleep for the past few days. I sleep max 4hours and I feel exhausted during the day which is not helping my depression. Has anyone on similar combo has been struggling with sleep? Does it pass? 

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  • Posted

    When i had disturbed sleep when first taking this combination i assumed it was due to the depression and it did improve as the medications started working and the depression lifted. I do still get vivid dreams but i don't worry about them. I hope this reassures you.

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  • Posted

    High Ala. Haven't had these in combination but have used both on their own. The mirt help with sleep but for me the venlafaxine disrupted my sleep. What type of ven are you on? If it's the XR version it's best to take it in the morning so as to minimise the disruption to sleep. It can take time to find a combination/dosage to suit everyone. I have been on ven since beginning of July (wrongly prescribed as later had to have dose lowered for Bipolar 2 diagnosis). Tried quetiapine for 4 and a half weeks and was then changed to Abilify which is helping alot more. If you are struggling with your sleep don't be afraid to ask your doctor if there are alternatives that could help you. All the best for a speedy recovery.

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    • Posted

      Hi Ala. Glad your sleep was a little better. It's so frustrating not getting any sleep. Hope your headache eases soon too. Always takes a wee while to settle into a new dose. Fingers crossed for you to get an even better nights sleep tonite. I have a whole arsenal of things to help my sleep: lavender spray, rescue remedy drops, chamomile tea, white noise app on my phone and the metal Indian head message thing you can buy off Amazon! . Maybe you've tried all these already. If not maybe they could help? Good luck. Xx

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