Do Dmard drugs change the way the body reacts to steroids

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hello, i have been using sulfasalzine for about 7months first 12 weeks on its own and since then with methotrexate injection ( started on pills made me so sick).  am now at 17.5mg a week took along time to get there as was so sick with the pills. 

i have not had any improvements since being on the meds although last week i had another steroid injection in my knee about the 10th one and it finally made a differance does this mean the other drugs are starting to work and have changed the way my body reacts to the injection because before this time they did nothing i also did a months worth of predisinone which also did nothing for me. 

i have been so pleased this week does this mean things are finally getting better or am i getting ahead of myself. 

thanks for any advice 

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  • Posted

    Taking some DMARDs at the same time as oral pred may increase the effect you get for the same dose of pred, it is called a steroid-sparing effect. I don't know if it does the same with injections though. 

    However - methotrexate sometimes takes up to 6 months to show a effect. Maybe you have finally got the benefit of that.

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  • Posted

    A steroid injection will only make you feel good for so long.If you are still struggling you could your consultant for more help
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  • Posted

    Hi, I've been on sulfasalazine for years, inflammation CRP started rising so Rheumatologist gave me methotrexate pills 15 mg dose, and after 1 week ended in A and E, bad reaction to methotrexate felt terrible and massive stomach cramps, so no more methotrexate, now being assessed for Biologicals, I did have one of those steroid injections worked OK, that's it with RA it's up and down just when you think you're improving you go back again, sorry to be so pessimistic, good luck.

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