Does pregabalin cause chronic fatigue

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I was prescribed pregabalin at the beginning of November 2019 for restless legs.

I take 100mg every evening, and it has stopped the RLS. However, since January I have been suffering again with chronic fatigue.

I have a diagnosed history of chronic fatigue going back to the 1990s when I was in my 30s, so know what CFS feels like.

My GP has done all of my bloods - diabetes, liver, kidney, thyroid, iron, Vit D, full blood. All of which have come back normal and the GP is at a loss to what is causing my CFS which is making me physically weak.

Does anyone on this forum know if pregabalin is linked with CFS please?

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  • Edited

    There are a lot of triggers for ME. I'm not a doctor but RLS sounds like something you can self test on. Try cutting your dose in half, or entirely.

    A related effect for me is medicine sensitivity. I'm a big guy, but i take a half dose of my diuretic when my weight would indicate a double.

    To be safe check with your GP.

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