Drowsiness as side effect imipramine for neurological pain
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Can somebody help with info on the drowsiness with imipramine?
Why? I like to think I’m optimistic but my symptoms are getting me down. I'm trying to get rid of drowsiness and fatigue after depression and on-going neuropathic pain; it gets so bad that at times I just don’t do anything in a day. I’m investigating several avenues, one of which is my medication. I take 100-150mg imipramine pd, 100-200mg Gabapentin/Neurontin and 100mg Provigil. Drowsiness is listed as a side-effect of imipramine but most references say it is normally short-lived and I had minor symptoms of drowsiness before I started it. I tried to cut down on it very slowly (-10% over 2 weeks) but after getting down to 80% (80mg pd) I had enough of what I put down as withdrawal effects (anal itching, bad RLS) and went back to a standard dose.
Relevant medical history. I’ve always felt a little more drowsy/tired than I’d expect (I’m now in my late 50s). 20 years ago I had a partial turbinectomy; with every cold I had my nose would hurt for a few days afterwards. 5 years ago I began to feel very drowsy after lunch, followed 2 months later by depression from divorce and work stress alongside RLS when I relaxed. I couldn’t take to Venlafaxine and changed to Imipramine. 2 months later, with my depression getting better on the medication, CBT and reduced stress, I had debilitating pain in my nose; an ENT specialist could find nothing wrong and a neurologist diagnosed Atypical Facial Pain; he prescribed Gabapentin/Neurontin alongside the Imipramine, then later Provigil to counter my drowsiness. I had a sleep study, was diagnosed with mild sleep apnea; a CPAP machine gave me good O2 levels and changed my desperate tiredness on waking to low tiredness; my wife reports I often have restless legs at night. My nose is mostly slightly painful with the odd flare up. 18 months ago I began to have tooth pain after a filling that is probably linked to my nose pain. I now consider that I’d be over the depression were my drowsiness and fatigue not frustrating and depressing me.
Typical example. 2 days ago I spent the day as if I had a lead sheet over my brain and shoulders that made any movement a feat of motivation; by 8 pm I felt as if I had a ton of weight pulling my eyes down so badly I was a wreck and wanted to die (figuratively not literally!). Today I woke up around 0700 after a good 8 hrs sleep. After breakfast I sat reading until 0930 when I fell into drowsiness where I spent 75% of the next 4 hrs sleeping without feeling refreshed. More Provigil and a coffee made me functional.
0 likes, 3 replies
icecool StrivingOn
Posted
Sounds like the sid3e efefects of the drugs. Are u B12 deficient? If so need Vit B12 injections. Pls don't ignore the tiredness need a full blood screening doing espeically foriron deficiency anaemia as well as B12 deficiency as stated previously. Sub linguql Vit B12 is not guaranted to be absorbed via the stomach.
ptolemy StrivingOn
Posted
StrivingOn
Posted
Thanks. I've had a bad week that has finished hopefully. I realised that a lot of the symptoms I'd put down to the drugs matched those of hypothyroidism (eg tiredness, high cholesterol levels, muscle cramps, cold hands & feet, putting on weight) and a few temperature measurements showed that I did have body temperatures notably lower than average, suggesting that might be the case. I've just had blood taken and am now waiting for the results. I'm trying hard not to get my hopes up as I've had painful dead ends before. Fingers crossed.