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Drug combo: Fluoxetine, mirtazapine and bupropion

Posted , 3 users are following.

michael64305
michael64305

I'm a male in my thirties and I've been on mirtazapine and pregabalin for a long time. I've just started weaning myself off the pregabalin and have started taking this triple combo. I'll use the brand names here so more people find this entry in google!! - Prozac, Remeron and Wellbutrin/Zyban.

Does anyone have experience of this combination? I'm particularly concerned about sexual side effects. Apparently mirtazapine stops the fluoxetine from causing sexual dysfunction...and bupropion doesn't cause sexual dysfunction in the first place. I need this combination to work as I'm at rock bottom - but cannot put even more pressure on my relationship by having no libido etc.

0 likes, 4 replies

4 Replies

  • deborah93854
    deborah93854 michael64305

    Posted

    Hi Michael,

    I take fluoxetine and mirtzapine and my sexual drive is fine. I a female.

    • michael64305
      michael64305 deborah93854

      Posted

      Thanks Deborah.

      Do you mind telling me how much of both you take? I'm taking 20mg of fluoxetine (two weeks tomorrow) and 30mg of mirtazapine. The bupropion appears to suppress a lot of the hunger pangs that come with mirtazapine. I've read that the higher the dose of mirtazapine the less likely you are to experience sexual dysfunction from the fluoxetine so I might go up to 45mg of mirtazapine.

    • deborah93854
      deborah93854 michael64305

      Posted

      I take 15mg flux and 30mg mirtz. I have been taking them for nearly 6 months, but I will be tethering off mirtz at the end of May.
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