Dry mouth with Metformin

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I was diagnosed with Type 2 Diabetes in 2011. I am currently taking Metformin SR twice daily plus Losartan, Atorvastatin and Omeprazole. For the past 15 months I have had an extremely dry mouth. I have it all the time.  It does not keep me awake but if I do wake up I am cotton mouthed until I have a drink.  In 2011  I had a wisdom tooth removed under Lidocaine (knocked me out completely). 2 weeks after this I noticed a dry mouth but thought it was to do with trauma after extraction. A year later I was sent to see dentist in Birmingham Hospital who told me the Omeprazole I take for a hiatus hernia was causing dry mouth. Apparently according to him it is notoriousfor it. My Doctor changed it to Esomeprazole and for 2 years I was free from trouble. Then 15 months ago it started again. I have tried coming off Esomeprazole and going back on to Omeprazole but no change. My doctor tells me to use artificial saliva and suck sugar free gums etc - this only makes it worse. Sacharine of any sort aggrevates a dry mouth. I am at the end of my tether now.  I have used every lip balm on the market but nothing appeases this dry mouth. Drinking a hot drink or a cold one eases it at the time but it is soon back. If I do eat anything sweet or savoury my dry mouth goes into overdrive like I am sucking a lemon. HELP.

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  • Posted

    What about a drug holiday?  Or perhaps eliminating one for a month at a time so you can identify which one (or combination) is causing the problem?  Since it is likely to be the Omeprazole/Esomeprazole then perhaps alternative treatments could be explored for your HH.  Unfortunately all drugs have side effects but when they are unbearable serious decisions have to be made: you are the patient and you are not there just to keep the doctors happy.
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    • Posted

      I hear what you say and I have been tempted to stop all medication. However, the omeprazole or a substitute is vital as the discomfort outweighs the dry mouth.  My cousin says the Metformin gave her a dry mouth and she got it changed but my doctor is reluctant to change mine. I am afraid to stop it on my own. I did change the omeprazole for ranitidine for my HH but it was totally useless .
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  • Posted

    I take Metformin SR 1000mg daily and don't really get a dry mouth but I've lost taste and smell to a large extent.  Not sure if this is a side effect or a symptom of diabetes.  If my sugars are high at night then I will get a dry mouth (easily solved by drinking water).  Could you try increasing your fluid intake?  Good luck... it may be that the dry mouth is the inevitable pay-off from vital medication.  For me, strict dietary control and exercise helps the most.
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  • Posted

    It is true Omeprazole / Esomeprazole​ (all of them) cause a dry mouth neutral How's your tongue, bright red, sometimes sore question I'd say your problem is Thrush, maybe talk to your GP about trying a course of Nystan smile
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