Posted , 9 users are following.
diagnosed with pmr in nov 2017. started with 30 mg now at 11 but have pain in the morning. I take 10 mg around 6 and most pain gone by noon. i take my 1 mg in the evening. seems that split dose has always worked well and wondering if now i should split 6 in morning and 5 at nite. suggestions?
0 likes, 6 replies
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bob03667 carlene22578
Posted
Over the past 8 months, I've gone from 20mg (10 and 10) to 9mg currently (reducing 1mg/mth).
Without changing the 11mg dose you're on, it seems to me it would be worth trying a different split such as 6 morning and 5 evenings, or 7 and 4. Still best to make any changes on the recommendation of a good rheumie.
I still experience some stiffness when I first wake up in the morning until I do a series of exercises.
nick67069 carlene22578
Posted
If you decide to split the dose, to have an effect on morning stiffness pills have to be taken as late as possible. If you are using non-coated pills try to take them just before going to sleep. When I took my split dose, I was taking it between midnight and 1AM. It takes 2-3 hours for pred to get into blood stream and cytokines ( the stuff that causes inflammation) is released at 4-4:30 AM . YOu want pred to be ready to prevent inflammation.
EileenH carlene22578
Posted
Why not add to the 1mg and take from the morning dose until you find the mix that works?
Michdonn carlene22578
Posted
Hi Carlene, I played around splitting my dosage and settled on 1/4 -1/3 at bedtime. I had the same problem stiffness and pain first thing in the morning. Splitting solved the problem. Good luck on the rest of your PMR journey stay active, positive with a smile. 🙂
patricia43291 carlene22578
Posted
Hi Carlene,
I had the same problem, early morning stiffness, until I did what Nick recommended. I take my pred, between midnight and two am. No problems now with morning stiffness.
Michdonn patricia43291
Posted
Patricia, I split for the same reason from 27/30 till 5mg on just on morning dose. 🙂