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Hi everyone. My mum has been on methotrexate for nearly a year now and on 5mg and 2.5mg pred alternate days. Her MXT has been increased from 10mg initially, to 15mg to 20mg which she has been on for the last 6 months. On the higher dose she has felt more tired and a bit sock at times. At today's rehumy appt, the nurse increased the weekly folic acid to twice weekly to help combat sickness. She also advised that for the first time, mums liver function was raised. Her ALT/AST has gone from in the mid 20s or 30s previously to 81. They are awaiting results of mums blood tests today and have said if they remain raised, rather than just being the blip it could be, they will ask mum to stop the MXT for a couple of weeks. We are worried first about the raised blood test and impact on liver, but also, what happens if the MXT has to be stopped. Has anyone had the same experience? Thanks for any replies.
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