Feeling really low again, does it mean antidepressants aren't working?

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Been taking mirtazapine for nearly 8 weeks now, had been feeling ok, not 100% happy but definately better. Had been able to do things with my day and felt good about myself most of the time. But been starting to feel sad again occasionally usually at night when i'm lying awake when i should be asleep. Been having difficulties falling asleep again, it's 5.15am and i haven't been to sleep at all yet.. I've cried a lot the last few nights for no real reason. I feel like after 8 weeks things should be getting better by now, does this mean the antideoressants aren't working?

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14 Replies

  • Posted

    What is the dose you are taking? I was on 15 mg for about the same amount of time and I was completely back to normal then suddenly like you I started to feel bad again. My doctor increased the dose to 30 mg so I am just keeping my fingers crossed that they will work.
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  • Posted

    My dose has been 30mg from the beginning. How long have you been taking the increased dose for now, do you think it is working for you?
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  • Posted

    I have been taking the 30 for 9 days. I feel a bit better today but I have felt like this other days and then the next day bad again. Others in this group say it takes several weeks to feel and to hang in. But if you feel down again after 8 weeks I am worried that this is a drug that you have to keep increasing. I really am sorry you are feeling down I know how that feels after you think you have finally got the right drug and dose.
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  • Posted

    People say that you can still have low moments whilst recovering, but that they become fewer with time and that it takes a shorter time for you to recover from them. I'm hoping that this may just be one of those times, I don't haven't felt any where near as bad as I have done previously and before taking medication. I'm already feeling alot better today, I had had a few bad nights sleep aswell so that usually greatly affects my mood when I'm exhausted. Hoping the mirtazapine will carry on working for me, and you too.
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  • Posted

    I have had a couple of really bad days but I have been a bit better for the last two days. Still feeling down

    but at least I feel like doing things. I am lucky that I don't seem to be having any side effects. When I first

    went on the 15 mg I couldn't stop eating but that hasn't happened with the 30. Also unlike you I don't have

    trouble sleeping. You have been very unlucky with it taking more than 8 weeks. Someone else in the

    group and said that she had been on 30 mg for 2 years and she felt great. She said it did take a couple of weeks for her to feel better.

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  • Posted

    Sorry to hear you are still feeling down. Yeah I haven't really had any side effects other that the tiredness and had increased anxiety in the beginning, but none of the stuff like nausea and dizziness etc.

    The trouble sleeping has improved again the last couple of nights.

    I was feeling better for a little while it took about 5 weeks for me to start feeling better, the sleep was better immediately, but after 8 weeks I had a few days when I was feeling low again, as I say I seem to be feeling ok again now though.

    I guess I'm just too quick to start thinking it's a disaster when I felt low again those few days.

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  • Posted

    I'm like you feeling it's a disaster. Not feeling brilliant today. All that keeps me going is that I know I will feel great in the evening. Do you find that?

    I am just going to Pilates at the local gym to see if that makes me feel better. I just can't wait for the morning when I wake up without that horrible feeling. I felt great the first morning after taking the 15 mg but there doesn't to be any letup with the 30.

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  • Posted

    Glad to hear you are feeling OK. Does that mean happy and back to normal? I know we are all different

    but I think I can relate to your experiences.

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  • Posted

    I've felt alright today, spent the day with a friend and had lunch. No I usually feel ok during the day, I had only started feeling low at night when trying to get to sleep. It had only been a few days though, I feel ok again now.

    I wouldn't say that ok means that I'm happy and back to normal, but I would say that it means I'm not sad, not stressed and able to relax and do things. It's difficult to explain how you feel, there's quite a big scale between being happy and being depressed.

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  • Posted

    Glad to hear you had a good day. I seem to be getting worse! I feel really down this morning but I do

    voluntary work at our local hospital today so I am hoping it will wear off. I am now onto my twelfth day and no sign of getting better. Did you find this? I really don't want to increase the dose again.

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  • Posted

    That's a shame you are feeling worse, but yes when I first started on mirtazapine I did feel worse before I started to feel any better.
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  • Posted

    Thanks for your message. I don't know if you experienced this but yesterday and today I felt dreadful when I got up. Then about mid morning I suddenly felt really goo. However I was bad again in the afternoon and evening as well yesterday. Then this late afternoon I am feeling good again. Did you find that it came and went when you were getting better. By the way do you live in the UK?
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  • Posted

    Hi, it hasn't been specific times of the day that I would feel good and then bad again, but I was very up and down at one point with the anxiety and depression, one minute I would be feeling relaxed and calm and just getting on with whatever I was doing, then the next minute I could become stressed out and agitated for no reason. That seems to have settled now though. Think it's most likely your body getting used to the medication. If it's very troublesome though no harm in going back to your doctor, and yes I live in Uk.
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  • Posted

    Thanks Sunset17
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