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Fexapotide

Posted , 17 users are following.

drummer10
drummer10

has anyone know where this new clinical trial is being held one shot shrinks prostate but it in trail not approved as yet but very promising so far google it!

0 likes, 22 replies

22 Replies

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  • Light1
    Light1 drummer10

    Posted

    I've been in contact with the company recently. They told me they have no upcoming trials. What did you hear?

  • derek76
    derek76 drummer10

    Posted

    Google said.

    1. PII trials (1). · 02. PIII studies in US (3). ·
    2. Feb 12: PIII study to start in EU [9]. ·
    3. Feb 13: A Safety Monitoring Committee review highlighted no safety concerns [16]. ·
    4. Apr 15: Recordati, the licensee in Europe, the Middle East, North Africa and South Africa, discontinued development and commercialisation activities in its licensed territories after two pivotal PIII trials for BPH conducted by Nymox failed to meet primary efficacy endpoints. Nymox expects to continue its development efforts for BPH in the US [23]. ·
    5. Jul 15: Nymox now intends to meet with authorities with extension data and to proceed to file where possible in due course for regulatory approvals for fexapotide triflutate in various jurisdictions and territories [24]. ·
    6. May 17: Nymox files for approval in five European countries, the Netherlands, UK, Germany, France and Spain [26]. ·
    7. Jul 18: Nymox resubmits an expanded application, which replaces the previous applications [27]. ·
  • rdemyan
    rdemyan drummer10

    Posted

    I was eagerly looking forward to this drug finally being approved. Last year, I thought it was dead in the water, but I just looked it up last week and it looks like they are still moving forward in trying to get FDA approval (they appear to be further along with EU approval).

    Several years ago I remember seeing an article where the drug was stated as reducing the prostate size by about 20% in the first month. However, the latest articles primarily use IPSS as a criteria and prostate size reduction is not really mentioned. Having been in startups that went belly up myself, I know the desperation of company founders when a company is going under. Only the most positive results are put forth and often greatly embellished.

    At any rate, I am still hopeful, but,,,,,,,,,,,

  • randal149340
    randal149340 drummer10

    Posted

    i would like more information sounds great

    • rdemyan
      rdemyan derek76

      Posted

      Not sure why you say that, Derek. Urologists will be the ones performing the injections. It probably won't be cheap. Also, the studies I've ready recently talk about multiple injections.

      While it will probably be less expensive than the other procedures, it will be a treatment under their control as opposed to FLA and PAE.

    • derek76
      derek76 rdemyan

      Posted

      I would think that others than urologists could do it. The price and who gets to do it will be controlled by the drug company.

    • rdemyan
      rdemyan derek76

      Posted

      From what I read, the shots are now directed into the transition zone. Maybe you're right, but I would want someone with an intimate knowledge of the anatomy to shoot me up.

  • ken19524
    ken19524 drummer10

    Posted

    There are certainly conflicting reports on the drug and on Nymox, the company marketing it.

    The marketing claims sound good but you would think that men who have been treated would be speaking up about their results.

    • rdemyan
      rdemyan ken19524

      Posted

      "The marketing claims sound good but you would think that men who have been treated would be speaking up about their results."

      Yes! The same thought occurred to me about a week ago when I was looking at FT studies. I actually tried to search for comments made by men who were part of the studies, but could not find anything. My guess is that the men were required to sign a non-disclosure agreement. If FT lives up to its billing, it would be a terrific advancement. However, there are so many questions about the company and what seems like covering up less than glowing information/reports.

    • derek76
      derek76 ken19524

      Posted

      Perhaps silence was their price for being included in the trials.

  • mike588
    mike588 drummer10

    Posted

    The most interesting no side effect treatment I've heard of since PAE - no heat sounds like the holy grail if it's true. I wrote to professor in Colorado (where I live) who hosted a video on the test results to ask him if he does it yet.

  • brian34488
    brian34488 drummer10

    Posted

    Hi, if it shrinks ones prostate what else does it shrink that they don't want to tell you about? drugs I hope one day there will be harmless drugs that work.

    • rdemyan
      rdemyan brian34488

      Posted

      My understanding is that they have injected the drug into other organs and tissue that are near the prostate of rats and dogs. Supposedly, in all cases, there were no negative effects.

    • mike588
      mike588 brian34488

      Posted

      its injected directly into prostate why would you worry and weren't they followed for 3 years? they can't lie about results in a study. They reported no side effects - anything else shrinking would be a side effect What i didn't see was median lobe mentioned.

    • uncklefester
      uncklefester brian34488

      Posted

      I've been watching this drug for about a year. If I recall, the drug is activated by the PSA produced in the prostate. It causes cell death but only prostate cells. There is another drug called topsalysin. Recent Information is kind of hard to find. If you stumble on something post it up. If your post gets "moderated" please PM me.

    • derek76
      derek76 uncklefester

      Posted

      I read cell death but is that shrinkage or a hole in the tissue ?

    • mike588
      mike588 derek76

      Posted

      good question, i'm guessing it shrinks at the target tissue dies and it reshapes itself after all the healing is done. i cant imagine it will look like swiss cheese after!

    • uncklefester
      uncklefester derek76

      Posted

      Google topsalysin then go to the manufacturer's website. They have a video of how their drug works

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