FUN Facts regarding Tramadol

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FUN Facts regarding medication Tramadol

For the Consumer

Applies to tramadol: oral capsule extended release, oral suspension, oral tablet, oral tablet disintegrating, oral tablet extended release

Tramadol (marketed as Ultram, and as generics) is an opiod pain medication which is used to treat moderate to moderately severe pain. When taken as an immediate-release oral formulation, the onset of pain relief usually occurs within about an hour. It has two different mechanisms. First, it binds to the μ-opioid receptor. Second, it inhibits the reuptake of serotonin and norepinephrine. (a hormone that is released by the adrenal medulla and by the sympathetic nerves and functions as a neurotransmitter. It is also used as a drug to raise blood pressure.)

As well as its needed effects, tramadol may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking tramadol, check with your doctor immediately:

You may experience some of these side effects if you discontinue use of  Tramadol.

More common

Abdominal or stomach pain








dry mouth

feeling of warmth

feeling sad or empty

feeling unusually cold


general feeling of discomfort or illness




itching of the skin

joint pain

loss of appetite

loss of interest or pleasure

loss of strength or weakness

muscle aches and pains



redness of the face, neck, arms, and occasionally, upper chest


runny nose


skin rash

sleepiness or unusual drowsiness

sore throat

stuffy nose



trouble concentrating

unusual feeling of excitement


Abnormal dreams

appetite decreased

back pain

bladder pain

blistering, crusting, irritation, itching, or reddening of the skin

bloody or cloudy urine

body aches or pain

change in hearing


cold flu-like symptoms


cough producing mucus

cracked, dry, or scaly skin

decreased interest in sexual intercourse

difficult, burning, or painful urination

difficulty with moving

disturbance in attention

ear congestion

ear drainage

earache or pain in ear

excessive gas


false or unusual sense of well-being

feeling hot

feeling jittery

flushing or redness of the skin

general feeling of bodily discomfort


headache, severe and throbbing


hot flashes

inability to have or keep an erection

itching, pain, redness, swelling, tenderness, or warmth on the skin

joint sprain

joint stiffness

joint swelling

loss in sexual ability, desire, drive, or performance

loss of voice

lower back or side pain

muscle aching or cramping

muscle injury

muscle pain or stiffness

muscle spasms or twitching

nasal congestion

neck pain

night sweats


pain in the limbs

pain or tenderness around the eyes and cheekbones

pain, swelling, or redness in the joints

skin discoloration


swelling of the hands, ankles, feet, or lower legs

tightness of the chest

trouble in holding or releasing urine

trouble with sleeping

troubled breathing

weight increased or decreased


Tramadol - You Need to Know (READ THIS)

Generic Name: tramadol (TRAM a dol)

Brand Names: ConZip, Rybix ODT, Ryzolt, Ultram

Tramadol is a centrally-acting, oral narcotic analgesic and is approved for the treatment of moderate to moderately severe pain in adults. The extended-release form of tramadol is for around-the-clock treatment of pain and not for use on an as-needed basis for pain. A combination product of tramadol and acetaminophen (Ultracet) is also available by prescription. In 2013, over 43 million tramadol prescriptions were written in the U.S, according to IMS.

In 1995, tramadol was originally approved by the U.S. Food and Drug Administration (FDA) as a non-controlled analgesic. However, since 1995, changes to the controlled substance status of tramadol have been made due to reports of drug abuse and diversion. The Drug Abuse Warning Network (DAWN) reported that roughly 20,000 emergency department visits were related to tramadol non-medical use in 2011. According to the National Survey on Drug Use and Health (NSDUH) in 2012, 3.2 million people in the U.S. aged 12 or used tramadol for nonmedical purposes.

1. ****Tramadol is now a controlled substance in all 50 U.S. states.****

On July 7, 2014 the U.S. Drug Enforcement Administration (DEA) announced that tramadol has been placed into schedule IV of the Controlled Substances Act (CSA) effective August 18, 2014. The new scheduling applies to all forms of tramadol. The rescheduling of tramadol comes at a time of growing concern related to abuse, misuse, addiction and overdose of opioid analgesics. Previously tramadol was a controlled substance in only a few states.

Starting August 18, 2014 tramadol prescriptions may only be refilled up to five times within a six month period after the date on which the prescription was written. After five refills or after six months, whichever occurs first, a new prescription is required. This rule applies to all controlled substances in schedule III and IV.

2. Tramadol is associated with a wide array of side effects.

In many people, tramadol is well-tolerated when used for pain, but tramadol can also cause some common and serious side effects. It is important to review with your doctor the side effects that have been reported with tramadol before starting treament Side effects with tramadol may worsen with higher doses.

Common side effects may include:









impaired mental abilities

Serious (but less common or even rare) side effects may include:


serotonin syndrome

depressed breathing

life-threatening allergic reactions

angioedema, or swelling under the skin

possibly fatal skin reactions

orthostatic hypotension (low blood pressure that occurs when you stand up from sitting or lying down)

suicide thoughts or action


Withdrawal symptoms may occur if tramadol hydrochloride is discontinued abruptly (DRUG ABUSE AND DEPENDENCE). Reported symptoms have included anxiety, sweating, insomnia, rigors, pain, nausea, tremors, diarrhea, upper respiratory symptoms, piloerection, and rarely hallucinations. Other symptoms that have been reported less frequently with tramadol hydrochloride discontinuation include panic attacks, severe anxiety, and paresthesias. Clinical experience suggests that withdrawal symptoms may be avoided by tapering tramadol hydrochloride at the time of discontinuation.

**FYI When you do Wean off of this medication. Just know you will be withdrawing from two different medications. One Opiod and the Other SSRI =(Double trouble)


Seizures have occurred in patients taking recommended doses but are more likely at high doses associated with abuse of tramadol.

*Do not abruptly stop taking tramadol as withdrawal symptoms like nausea, diarrhea, anxiety, or tremors may occur. Consult with your doctor for a tapering dose schedule if you are stopping tramadol treatment.

3. Dangerous drug interactions are possible with tramadol.

Tramadol may cause a dangerous condition known as “serotonin syndrome”. Patients receiving serotonergic drugs such as the migraine agents called “triptans” may be at a higher risk for serotonin syndrome. Brand names of triptans include Imitrex, Zomig, Frova, Maxalt, Axert, Amerge, and Relpax.

Do not take tramadol if you have used alcohol, sedatives, tranquilizers, or narcotic medications. Tramadol should not be combined with these medications or with alcohol at any time. Patients should avoid driving or other activities that require mental alertness until the effects of the drug are known.

Patients should always have a drug interaction review completed each time they start a new medication, including herbal, over-the-counter, and supplement drugs.

4. Tramadol can be habit-forming.

Tramadol is structurally related to the opioids like codeine and morphine and can lead to psychological and physical dependence, addiction, and withdrawal. People with a history of a drug-seeking behavior may be at greater risk of addiction, but illicit actions to obtain the drug can occur in people without a prior addiction, as well.

Do not abruptly stop taking tramadol as withdrawal symptoms like nausea, diarrhea, anxiety, sweating, difficulty in sleep, shivering, pain, tremors, or rarely, hallucinations may occur.

Consult with your doctor before discontinuing tramadol treatment; do NOT discontinue treatment on your own. Withdrawal symptoms may be relieved by re-initiation of opioid therapy followed by a slow, dose reduction combined with symptomatic support, as directed by your doctor.


The most common adverse reactions include nausea, constipation, dry mouth, somnolence, dizziness, and vomiting.


CNS stimulation has been reported as a composite of nervousness, anxiety, agitation, tremor, spasticity, euphoria, emotional lability, and hallucinations. During clinical trials, tolerance development was mild and the reports of a withdrawal syndrome were rare. Symptoms of a withdrawal syndrome have included: panic attacks, severe anxiety, hallucinations, paraesthesias, tinnitus and unusual CNS symptoms (i.e. confusion, delusions, personalization, derealization, and paranoia).

Very common (10% or more): CNS stimulation (up to 14%)

Common (1% to 10%): Anxiety, euphoria, nervousness, sleep disorder, insomnia, depression, agitation, apathy, depersonalization

Uncommon (0.1% to 1%): Emotional lability

Rare (less than 0.1%): Hallucinations, nightmares, dependency

Very rare (less than 0.01%): Withdrawal syndrome


Rare (less than 0.1%): Anaphylaxis, allergic reactions such as dyspnea, bronchospasm, wheezing, angioneurotic edema, swollen skin]


Very common (10% or more): Nausea (up to 40%), constipation (up to 46%), vomiting (up to 17%), dyspepsia (up to 13%)

Common (1% to 10%): Dry mouth, diarrhea, abdominal pain, flatulence, sore throat, gastroenteritis viral

Uncommon (0.1% to 1%): Toothache, appendicitis, pancreatitis

Nervous system

Very common (10% or more): Dizziness (up to 28%), somnolence (up to 25%), headache (up to 32%),

Common (1% to 10%): Confusion, coordination disturbance, tremor, paresthesia, hypoesthesia

Uncommon (0.1% to 1%): Migraine, sedation, syncope, disturbance in attention

Rare (less than 0.1%): Epileptiform seizures

Postmarketing reports: Seizures

Epileptiform seizures primarily occurred following administration of high doses or following concomitant treatment with drugs that lower the seizure threshold or trigger seizures.


Very common (10% or more): Pruritus (up to 11%)

Common (1% to 10%): Sweating, rash, dermatitis

Uncommon (0.1% to 1%): Cellulitis, piloerection, clamminess, urticaria, toxic epidermal necrolysis, Stevens Johnson-syndrome, hair disorder, skin disorder


Common (1% to 10%): Menopausal symptoms, urinary frequency, urinary retention, urinary tract infection

Uncommon (0.1% to 1%): Difficulty in micturition, hematuria, dysuria, cystitis, sexual function abnormality


Very common (10% or more): Flushing (up to 15.8%)

Common (1% to 10%): Vasodilation, postural hypotension, chest pain

Uncommon (0.1% to 1%): Palpitations, myocardial infarction, lower limb edema, peripheral swelling, hypertension, increased heart rate, peripheral ischemia, EKG abnormality, hypotension, tachycardia

Rare (less than 0.1%): Bradycardia


Very common (10% or more): Asthenia (up to 12%)

Common (1% to 10%): Malaise, weakness, pain, feeling hot, influenza like illness, rigors, lethargy, pyrexia

Uncommon (0.1% to 1%): Tinnitus, vertigo, ear infection


Common (1% to 10%): Anorexia, decreased weight, increased blood glucose

Uncommon (0.1% to 1%): Gout

Rare (less than 0.1%): Changes in appetite


Very rare (less than 0.01%): Syndrome of inappropriate antidiuretic hormone secretion


Uncommon (0.1% to 1%): Anemia, ecchymosis


Uncommon (0.1% to 1%): Cholelithiasis, cholecystitis, ALT and AST increased, abnormal liver function tests


Common (1% to 10%): Miosis, visual disturbance, blurred vision

Uncommon (0.1% to 1%): Lacrimation disorder

Frequency not reported: Mydriasis


Uncommon (0.1% to 1%): blood urea nitrogen increased


Common (1% to 10%): Hypertonia, arthralgia, back pain, limb pain, neck pain, muscle cramps, muscle spasms, joint stiffness, muscle twitching, myalgia, aggravated osteoarthritis

Uncommon (0.1% to 1%): Joint swelling, joint sprain, muscle injury, leg cramps

Rare (less than 0.1%): Involuntary muscle contractions

If you don't know. Now you know. I learned the hard way.

I am happy to say I no longer "need to" ingest this what I affectionately name "evil drug" anymore. I use other ways to manage my discomfort. Ice, stretching, Tens Unit (TENS, or transcutaneous electrical nerve stimulation, is a back pain treatment that uses low voltage electric current to relieve pain) Heat, massage to name a few.

3 likes, 6 replies

6 Replies

  • Posted

    And to think the doctors once said tramadol is not addictive! How wrong were they!

    Luckily they never helped my pain as I have an addictive personality and from what I'veread about withdrawals its a horrible drug to detox from!

    • Posted

      Exactly Katz31. That's what my doctor told me 2 yrs ago when I was rear-ended at a stop sign. I already have issues with back, herniated discs, bulging disc, degenerated disc disease and then the whiplash doctor called a blacklash?..Doctor tells me not to worry Angel this is not addictive like Norco's,  and other Opiods, its safe. You can't become dependent on this medication. Yeah, then I believe just last year 2014 he tells me there's a new law and the DEA has this on the list etc. I thought Great. But you told me....

      I don't think they really know how harmful some of this sh*t really is. They probably test lab rats for crying out loud. Like the rat is going to say I have really bad Withdrawals Stop giving me this.

      I was 2 yrs in and I decided I didn't need it anymore. I still felt the pain. So I had to use the ice anyway. I didn't want to "NEED" any more medications. I started to notice that when I missed my second dose by 30+ minutes I started to feel sick, nauseated, sweaty, anxiety, (withdrawal symtoms).

      I didn't like the fact that if I forgot to pack my second pill and take it with me. Where ever I was I had to go back home to take it. I could be, visiting my mom, movies, church. It didn't matter I was driving back home. Sucked! used to make me so angry.

      I knew by then I "NEEDED" it. My body told me so. That's why I thought it's time to get off this crap. I hate feeling like I "NEED" a pill to feel NORMAL.

      I tell my doctor I'm ready to stop and he prescribed me Clonodine, Ppramipexole (Mirapex) for Restless leg symdrome, and Xanax.

      6 weeks later after going through Tramadol Wean Hell. I made the mistake and told him I was being awaken by panic attacks. Xanax helped with that. So he decides to prescribe me Zoloft to help with that.

      At the end of my Tramadol Wean? great. So I took the Zoloft and only lasted 4 days of evil. I felt like I was going insane litterally. Just sick 24/7 I closed up my house. Drew the drapes. I didn't want to see the sun. Didn't wanto talk to anyone. I only had strength to walk to the bathroom and back to my lazy boy chair...mind you I have to take care of my sick mother (at the time) and I also have a aging sick little dog that needs to be hand carried outside to relieve herself. Only weighing about 10lbs...feeling like 100 lbs to me. Hating life. (that was not like me to hate life. My good natured, optimistic persona had vanished.

      My plan was to Wean off Tramadol and then Xanax. But then Zoloft came into play. Messed me up.....I wrote about my nightmare with that here.

      During the times I felt a little better probably do to Xanax? I started researching about what the hell I was taken and I found this forum. It didn't matter that it was in the UK and I in the USA I just wanted some kind of answers.

      I didn't have the mental capacity to do lots of research and understand during my Wean from Tramadol. Zolof made my brain so numb, dazed and confused, headache 24/7 no appetite, loose stools all day and night. Fun, My quality of Life had gone down hill QUICK.

      I had no symtoms while on Tramadol until I tried to get off. I didn't know it also contained an SSRI so when Withdrawing from this Evil drug you have to Wean off of TWO medications in ONE. SSRI and Opiod

      I'm not on SSRI's or any other Psyche Meds. So my body is sensitive to all these powerful drugs. These drugs might help Others. But it's NOT for Angel. I'll pass. In fact I rather have a cold beer instead. Which I have not touched in a long time.

      My next challenge will be to WEAN off of Xanax 0.5mg yes, some say it's a small dose. But not for Angel. I can feel the withdrawal symptoms now from Xanax. I plan on Weaning soon. I've created Medication Log's so I know when to take what medication and at what time, and not to go over x3 Xanax in one day. To this day 5/31/15 my awesome sharp memory is not quite Normal yet. I don't rely on it right now. I use logs and alarms I have on my cell phone.

      And I recently developed asthma like symtoms. It makes me cough when I speak and I have a wheeze in my lungs. I asked the pharmacist and she says it takes awhile for Zoloft to leave the system. I told her it had been a week. She seems to think that Zoloft is the culprit? I don't know but I need to ask my doctor for an inhaler now. Its not from a cold or flu. I don't have allergies..something's not right with my lungs. I bought some cough medication but it does not help. I'm not a smoker and never have been. 

      Some people have defended Tramadol. They have denied all symptoms listed above. Well,  in my experience (only 2yrs) I didn't have any symptoms either. However, I'd sure like to hear them defend Tramadol after being on it 2yrs or longer and decide they want off of it. Again I was only taking 50mg x2 per day as directed.

      Good phucking bye Tramadol, and Zoloft. Good riddance! and next The Xanax Wean..oh yeah, this should be allot of joy as well.

      Xanax you will be replaced by something more fun for me, an alternative. And when all is said and done. I'm going to throw me a bad ass bar b que party to celebrate getting off those evil medications.

      I'll be making lots of good food and bar b que sauces all from scratch. I'm going to enjoy entertaining family and friends.

      The only ones that will know why and how will be my faithful wife and I.

      I'm going to celebrate taking Angel's Life Back.

      Stay tuned

      USAngel from The Bay, California style

    • Posted

      been using tramadol almost 9yrs can i stop taking this evil pills??? 
    • Posted

      btw,whether these drugs cause me hard to conceive? because I've been trying for almost 10 years to get pregnant..


  • Posted

    The doctors simply bought what the Pharma Reps told them. There needs to be a way to reign those guys in. They serve a purpose, but stronger regulations are needed. And doctors need to do as much of their own research as they can, and not depend just on what they are told.
  • Posted

    I have a genetic connective tissue disease. I have,had muscular and joint pain for over 20 years. I can not tolerate opids so several doctors have suggested other meds. I was told I could never take serotonin and today discover that maybe 50% of my new pain after 2 weeks on tramadol 100 mg a.m. and again p.m. is a side effect of both drug. I have been dissy,scratching my skin till it bleeds,using ice and heat pad,hot baths,etc. I have had horrible headaches,stumbling,hurting so bad in my neck I can't sleep. I am tapering off. Still have nothing for pain. Doctors need to be more careful

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