Giving up methotrexate for pregnancy

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I'm turning 25 soon, and have been on methotrexate for the past 12ish years for psoriasis. I'm on 20mg/week injections and if I try to reduce my dose, it flares up so much that I'm too scared to reduce it again.

Although I'm not planning to have children soon, I am becoming aware that in the next few years I might be. Wondering if anyone has been in a similar position, and what alternateves were offered to you to cover the time it isn't possible to take methotrexate? 


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  • Posted

    Hi Melanie don't know if the same but I was speaking to a mum & she had to come of methotrexate to try for children & they gave her steriods throughout her pregnancy x
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  • Posted

    Hello Melanie,

    I had Rhuematoid Arthritis for 2.5 years and I was given all three - Methotrexate tablet/injection (for a year), steroids (for a year) and Sulfasazine/Folic Acid (still taking it) as I am currently pregnant.

    I reduced the Methotrexate (MTX) slowly is the best way so you know whether you can reduce the next dose or get a flare up (make notes of it if you do get a flare up). This was advised by my specialist while staying on Sulfasazine as I know this tablet is safe to take it during pregnant. That's all I know.

    I suggest to start talking to your specialist regards to your future plan incase so you are prepare when you want children.  The specialist can start looking into it and start looking into alternative medication for you while on MTX.

    Don't be scare to reduce it and be positive, this is probably the only way to find out. I have experience flare up when I was advised to stopped MTX after 8 months due to flare up with my liver due to increase of my MTX doses and had to wait until my liver status was back to normal before I can go back to my normal MTX doses. It wasn't a pleasant experience but at least you know sooner than later.

    Hope that helps. 

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