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  • kat54641 1

    Major appetite changes with methotrexate

    I have been on injectable MTX for 4 months now and not only have i lost weight (12 pounds-which i probably needed) but am experiencing major appetite changes. Eg. I used to love chocolate... It was my middle name!! I seem to have no desire for it and other goodies i used to love. Anyone experiencing...

    5 replies 0 votes Last reply
  • mary00571 1

    Is methotrexate causing my weight loss and decreased appetite?

    I have arthritis and was recently (in the past month and a half) put on methotrexate tablets (6 a week) and im also taking a 1mg folic acid supplement 5 times a week (excluding the day i take my MTX). Ive noticed ive lost a couple pounds and i have no appetite whatsoever. I dont have really bad nausea...

    5 replies 0 votes Last reply
  • carrieann 64399 2

    weight gain and Methotrexate

    I have using methotreate for almost 3 months I am on 20 mg once a week.... and I have now gained 10lbs.... I was wondering if this a common side effect for others..... thanks

    41 replies 4 votes Last reply
  • kristy7 2

    methotrexate toxicity fatality

    Dear Methotrexate Gang, Hi - I'm writing this post because my father has passed away from methotrexate toxicity in February. This cause of death has been officially confirmed. I'm in a state of shock and I really don't believe that the general public understand the severity or danger of this drug. ...

    62 replies 3 votes Last reply
  • lisa63151 1
  • lesleybt 1

    Reducing methotrexate

    I've been on methotrexate for 5+ years taking doses between 17.5mg to 25mg. Was on 20mg and consultant recommended reducing to 17.5 and even 15 if can tolerate. Have been on 17.5mg for 4.5 weeks now, and am feeling rubbish. Don't know if it's related or not or if RA is just more active due to weather,...

    7 replies 0 votes Last reply
  • jill62417 2

    Side effects

    Hi , I was diagnosed with RA 12 months ago. I was immediately put on prednisone. Since then I have been put on Arava which I had awful side effects  from so was taken off it while test were done and prednisone increased again. They tried me on the Arava again but still severe side effects. I was then...

    5 replies 0 votes Last reply
  • sarah96274 1


    Hi all I'm due to start taking this drug soon. I've had an chest x-ray done witch was told was normal.... But now I've had a letter from the hospital saying I need a heart and lung test..... is this normal to have done before hand?

    6 replies 0 votes Last reply
  • freyja00438 2

    Switch to Methotrexate Injection

    I've been on 20mg oral methotrexate for almost a year for my psoriatic arthritis. Makes me feel sick, insanely tired, just generally gross. My rheumatologist has switched me to injection. I was supposed to take the tablets on Friday but had to wait til today because I had to have a nurse with me for...

    2 replies 1 vote Last reply
  • Guest M

    Methotrexate, Shortness of Breath and Increased Heart Rate

    On Friday, I got up from my desk to make the short walk to the toilet, after which I was a complete mess, I couldn't catch my breath, I was sweating and my heart was pounding. I took myself to the company first aider who recorded my pulse at 98bpm. She recommended I went to the doctor which I did on...

    10 replies 1 vote Last reply
  • shirlee86000 3

    Don't like being on methotrexate but it really works for me

    We hear all kinds of negative things regarding methotrexate I also have had a few side effects but I wanted to start a discussion on it's good side. It really has helped me be pain free, yes my hair has thinned slightly but a small price, all in all it's a wonderful drug, I know it's toxic etc but without...

    7 replies 1 vote Last reply
  • kirsty15373 1

    MEthotroxate help

    Hi, I'm hoping for some help. I've been taking methotroxate now for 6 weeks for rheumatoid arthritis and although it has helped enormously with the pain I am suffering with my mental health quite badly from it. I have previously suffered with depression although some years ago and all of a sudden I have...

    5 replies 0 votes Last reply
  • andyfy6 1

    Methotrexate and Smouldering Myeloma

    I am currently on 15mg of Prednisolne which helps a difficult eczema like condition, to mitigate the long term effects of steroids my dermatology consultant suggested looking at Methotrexate. I have Smouldering Myeloma (diagnosed in 2011) and I am concerned that Methotrexate may move me from a smouldering...

    2 replies 0 votes Last reply
  • kirknap 2

    Methotrexate and alcohol

    Hi there, I've only yesterday started on my methotrexate tablets and have just started reading the online forums and have became very worried! The number of people who are losing their hair seems incredible, is this a common side effect? I'm 23 years old and drinking and work in a bar while i'm studying...

    104 replies 5 votes Last reply
  • barbara93798 2

    Hair loss

    Hi can anyone tell me is it normal to have hair loss when on methotrexate I have been taking it for over a year. I have lost hair under my arms, on my legs and my arms. My hair on my head has become thin and like a babys hair. Not sure if it is that drug or something else I use. Hope to hear your replies.

    8 replies 0 votes Last reply
  • joe88085 2

    Methotrexate side effects - blisters- how long?

    a few days after starting MTX i developed severe blisters on my lower lip and  nightly peeling and bleeding.  its been a week since my last dose but no subsiding in the blisters.  After 3 weeks of MTX my doc has switched me to mycophenolate.  How common is this blistering side effect and how long before...

    4 replies 0 votes Last reply
  • tricia1982 2

    Cold sores

    Hi can someone please give me advice got started on methotrexate a week ago the day I took it I felt sick but the day after I felt dreadful feeling sick, feeling exhausted and my joints were killing me. I now have a massive cold sore on my lip is this normal????

    10 replies 0 votes Last reply
  • Wheato 2

    Tips for avoiding hair loss on Methotrexate

    Hi everyone, I have RA and have been taking Mtx for about 6 years. I take a high dose folic acid supplement every day apart from the day I take my Mtx. I am also on Humira injections every other week. When I ran out of folic acid a few years ago I lost masses of hair and (at the time) hadn't realised...

    33 replies 3 votes Last reply
  • scott59075 1

    Methotrexate "bad day"

    Hi all, ​    I was prescribed methotrexate injection (25 mg) weekly after having gastro issues with Cellcept and Imuran.  I have been on it for 3 years.  I am also on daily folic acid and Leucoveran.  I have always had what I call a bad day after my injection.  3 to 6 hours after the injection, i start...

    2 replies 1 vote Last reply
  • leonard12916 3

    Having difficulty walking from reducing steroids, looking for advice!

    Over the last 2 months I've reduced from 7 to 6 mg of Prednisone at the advice of 2 of my doctors.  The results of this are that my knees have become very sore along with muscles in my legs thereby making it harder and harder to get up and walk.  Lately even my shoulders hurt and my biceps ache; I'm...

    1 reply 0 votes Last reply
  • kelly2804 1

    Methotrexate weight gain and weak bladder.

    okay I know the doctor says there should be no weight gain but I have been on 25mg per week now for three months and have gained about 7 kilos.  I have started to monitor my eating and it is around the calorie intake prior to going on or less and I was slowly losing weight at that eating level.  Also...

    2 replies 0 votes Last reply
  • leonard12916 3
  • jacob75577 2

    INCREASED PAIN from Methotrexate!!

    I took my first dose of 6 - 2.5mg pills last night for my arthritis.  Woke up a few hours later in the most excruciating joint pain I have ever had--in EVERY joint including my knuckels of my fingers.  Anyone ever experience this crazy reaction to this medication??

    46 replies 0 votes Last reply
  • GeorgiaToddy 1


    I am 21 years old and around about 4 years ago I began to have swelling of my knee. I have had one x-ray and two MRIs in this time and both have come back negative. I have been to my local hospital and been transferred elsewhere. I have been diagnosed with arthitis and also been told no one really knows...

    4 replies 0 votes Last reply
  • davidmb13 1

    Stomach pains

    Hey all, I took my first dose of 12.5 mg of methotrexate last Saturday night. About four days later, I started having stomach pain. It's been about three days now and it's been constant. I've been taking the 1 mg of folic acid every day. I've tried Prevacid and bentyl but neither have helped. Has anyone...

    6 replies 0 votes Last reply
  • sunny25366 2

    Questions about MTX and alcohol

    I'm getting ready to take my 2nd dose of MTX 15mg for Lupus. I am a 57 yr old Caucasian woman diagnosed in February (onset was in December!). I noticed after the first dose I was sick that afternoon and next day nausea and diarrhea but it got better every day after that. No hair loss at all! The MTX...

    4 replies 0 votes Last reply
  • trev1986 2

    bad side effects

    iv been on methotrexate from around december 2016 started off fine but recently started feeling awfull chest pains, headaches blurry vision to the point were i feel anxious and very panicky at times, iv had one from what i can decribe as a panic attack, iv never suffered anything like this before and...

    16 replies 1 vote Last reply
  • Charlie.Chatz 2

    About to start Methotrexate

    Hi all, So I am about to start my first, test dose, of Met. tonight for my Psoriasis. I chose to take it with my evening meal as A. I don't want to find out about the initial side effects while I'm at work and B. I will hopefuly sleep off ay of the side effects.  I will be taking the Folic Acid once...

    20 replies 0 votes Last reply
  • Erika 1234 2
  • paul82428 1

    Iritis and methotrexate

    Hi  I have been suffering recurrent iritis have been using maxidex and timolol, the eye hospital want me to start methotrexate 12.5mg for 2 weeks then 17.5mg after that if all the blood tests are ok been reading about this medication sounds like it could be a bit of a nightmare with the possible side...

    1 reply 0 votes Last reply
  • tia35000 2
  • j.capes 1

    Methotrexate Injections

    Hi, I've been on methotrexate injections now for about two years. Prior to this I was on the tablets and had to change to the injections because they made me feel very sick. After the two years on these injections I'm also starting to feel sick for quite a long period after I inject. I'm not sure if...

    10 replies 1 vote Last reply
  • robertcosmos 2

    Great help with GI side effects

    Chlorella and Spirulina are apparently known to help with the bad effects of chemotherapy on the body.  As most will know methotrexate in very high doses is used as a chemotherapy drug.  So I tried them and I believe they have significantly helped alleviate the impact of methotrexate on my digestion....

    0 replies 0 votes Posted
  • judith09301 2

    Does everyone get side effects from MXT?

    I will be taking my first dose of MTX this week for my RA after putting it off for half a year.  Reading through the discussions on the forum I am getting the impression that everyone gets unpleasant side effects of some sort. Does anyone know if there are people who have not had nasty side effects?...

    28 replies 0 votes Last reply
  • Pesh0308 2

    I started taking methotrexate last night..

    I started taking methotrexate last night, 4 pills,, have been taking folic acid about 2 weeks and I feel terrible today.  It seems every ache I have had in the past due to RA is magnified.  I also feel bad In general, fatigued, tired, sore.  Is this normal?

    55 replies 1 vote Last reply
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