Leg pain worse at night

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I have been on Methotrexate prescribed by my RA specialist for 11 months and only today my GP has said that it COULD be down to this drug and has written a letter to the specialist asking his advice. (No idea how long it will take for him to answer) The pains I'm having in other parts of my body I can just about put up with, but the pains in my hips, thighs and lower legs are unbearable, much worse at night, deep inside, they hurt so much that I can't tell whether it's in my bones or nerves! There is absolutely no way to lay on my sides, I can't find a comfortable way to lay in bed at all, so I'm up and down like a yo yo, lucky to get an hour and a half sleep at a time, I am so tired! In the day the pains ease a little bit, it depends what I'm doing, walking hurts, lifting my legs in and out of the car hurt, climbing stairs hurt, getting up or down to a kneeling position hurts. My knees, ankles and feet are the only part of my legs that don't hurt!! I mentioned all this to my specialist during my last appointment but he said it was probably down to the statins that I was taking, so I stopped them for two months and it made no difference at all, the pains are just getting worse and worse, I dread going to bed. I was on predisolone for my PMR and as I was reducing the dose the leg pains started. The specialist told me to go back on them but I don;t want to mask the pain, I want to know what's causing it. Has anyone else had the same experience? Is it the Meth? Will it get better? Someone help me, I'm begging? I can't take it anymore.

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5 Replies

  • Posted

    Hello Ann, I am sorry you are suffering like this. I recognise the symptoms. I took Methotrexate [MTX] for very nearly 2 years, as a steroid sparing agent for my autoimmune disease. I am under a Dermotologist for that. I actually managed to come off the Prednisolone for a few months.

    while I was taking the MTX.

    I tolerated the pain I was getting for as long as I could but eventually stopped the MTX. My Derm thought it was the Prednisolone that was causing the pains but it wasn't. I also had the same problems with pain when I took Statins = I took those for 2 years too.

    If I was in your boat, I would stop the MTX & telephone the Rheumatologist's secretary & ask for an urgent appt..

    I went back on Prednisolone. For my condition, I then took Mycophenolate Mofetil - my body only seems to tolerate these drugs for about 2 years.

    You can stop the MTX & you won't suffer withdrawal symptoms like you do with Pred. You need to see your Consultant Ann, not your GP. Good luck & don't suffer!

    [Oh & make sure you have a DXA scan to check your bone density if you have been taking steroids]

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    • Posted

      Thankyou mrsmop, I am just waiting for my blood test results, which should be in by Tuesday, I will post my results, if anything shows up, and also waiting for the consultants appointment. I am so interested in the toxic side effects of these drugs that we are given.

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    • Posted

      All my blood tests came back normal, which is good, my Dr thinks it is the Methotrexate . The specialist can't see me before second week in January but the helpline is meant to ring me back on Monday. Are you sure there is no problem with coming off the full dose of Meth? or should I cut down slowly?, I hope it's the former because I am going crazy!! xx

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  • Posted

    good morning

    i deff know the pain your going thru

    i have exactly what you just mentioned

    im also having painon my feet im suppose to start mexo tonight im so scare but i need relief im so misreable 😦

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  • Posted

    Maria 314, I'm so sorry to hear that you are also in so much pain. What is mexo? Do you mean methotrexate? I will be posting my blood test results in a few days.

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