Going off Mirtazapine, but can I take Benadryl ???

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I have been on Mirtazapine for almost 9 years.  But nervousness, anxiety, it only got worse... So definitely want to get off.

I know I have to taper slowly and it will take a year.

But the WD I expect from beginning is insomnia .

My thought was , as Mirtazapine is sleep inducing because it is has histamine H1 receptor affinity… maybe taking a bit Benadryl to avoid the  “not sleeping” WD could make it easier to me.

Of course not full Benadryl tablets and not for to long, maybe just a few days, at every drop down.

( Even if only placebo ) .

FB groups say it should be avoided , but no more info.

Any thoughts ?? Anybody tried it ??  Thanks

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4 Replies

  • Posted

    have you considered asking your doctor for a sleeping pill?  5mg of zolpidem Tartrate tabs will do the trick.
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    • Posted

      That an option , but as I already take 10mg Valium in mornig, 10 in evening , plus 0,5 Xanax..... inn the normal days , thus when I do not add an extra xanax or 2 :-) ... 

      So I was kinda trying to avoid this approach.


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  • Posted

    Hi Maurice,

    I see your thinking, if you taper slow enough you won't need any other sleep aid.  Do you still sleep OK now?  

    Yes most support groups I have read say not to take extra anti histamine.   Because your brains neuro transmitters need to heal with the slow tapers, and adding more histamine block (like Benadryl) stops this.  

    Maybe do 5% drops to begin with, see where the land lies with your own body/mind, and if after 3 weeks you are OK maybe tip toe up to 6, 7, 8% according to how you feel every 2-3 weeks.  

    Are you planning to make a liquid?

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    • Posted

      Hi Thanks,

      I am not sleeping OK , it was only better in the very beginning.

      In the meantime I also found that Benadryl is also Serotonergic, so combining the 2 is indeed not a good idea. 

      ( Even if some Doc's prescribe 2 AD's to some people )

      But my biggers fear is that taper the Mirtazapine will make me sleep even less. 


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