Has anyone combined an SSRI and Lyrica ??

Edited , 3 users are following.

Hi all,

New to the group - I have had a rollercoaster of anxiety over the last months, however have suffers from GAD since a kid.

I have recently been prescribed a various amount of tablets and needed to get off them as I didn't know my Arsenal from my elbow and the anxiety was still rife after 6 weeks.

Recently I was prescribed Lyrica with a few other tablets, however I wanted to know what worked for me and that Was difficulty when you are on so many different tablets, so I came off all and stayed on Lyrica to see its effects.

The Lyrica has definitely assisted and im currently up the dosage to 150mg x2 for the last 2 days, however I still believe I may need a SSRI as well to accompany the Lyrica and have read a lot of studies.

Just wondering has anyone had success with a SSRI and Lyrica combined ?

Many thanks

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5 Replies

  • Posted


    You have been prescribed two different medications, there must be a reason for this so you need to take them as prescribed.

    If you feel the one tablet is working tell your GP although at this time I would understand why you have gone against His recommendation. Many people on these medications find it takes about six weeks for them to work so you need to allow that time at least before you an take recommndation not to take the other group of tablets as many types control different parts of your complaint.


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    • Posted

      Thanks Bob,

      Really appreciate your response.

      My GP is aware that I am just on Lyrica now, and on this basis the dosage was increased from 75mg x 2 to 150mg x 2 to see if the Lyrica would be sufficient to grasp my anxiety. I'm not sure if you have come across Lyrica before but it's not an SSRI or SNRI - it was originally prescribed for pain relief and as far as I am awareness doesn't take the usual 4-8 weeks to take full effect . I would prefer to not to be taking a SSRI or SNRI and I do find that the Lyrica does help with minor side effects (for me) and I also feel myself - If that makes sense but it I don't think it's completely doing the job with my anxiety. I am on 300mg per day and the max dose is 600mg.

      There doesn't appear to be many people taken Lyrica in comparison to SSRI, and in just wondering if there is people taken both and have found it beneficial ? I do believe the properties with Lyrica have assisted but as I said not to the level I quite need for my anxiety without testing a higher dose. I don't even know how long it takes for the Lyrica to take full effect - however I believe week.

      Thanks again BOB, just trying to get some feedback and appreciate your response

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    • Posted


      I may have heard people taking your medication, although I reply on  a selection of sites, on of them Pain medications. If you take pain meds the working time is of course a great deal shorter and the drug over time bunkers up.

      If you are happy with your lot at this time, and you are willing to accept any limitations, carry on. The situation we all need to take into consideration if it is not broke, do not fix it. As your GP is in partnership with you as far as your health is concerned

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    • Posted

      Thanks Bob, please do let Me know if you come across people that take an SSRI with Lyrica and have success as that's the combination I will most likely need - notwithstanding that everyone different

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  • Posted


    I m also new to the group. I have also been using escitalopram 20 mg for 8 years for GAD but i have not been totally recovered. Now from the last 5 days I have added pregabalin 150 mg. I will wait for a month and will then inform you about the combined effect of an SSRI and Pregabalin.

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