Has anyone tried Mirtazapine with or without venlafaxine?

Posted , 11 users are following.

I wondered if anyone had any degree of success with mirtazapine with venlafaxine especially. I am currently withdrawing from 225mg of efexor as it is no longer working. Can mirtazapine be prescribed by a gp? I am worried that my depression will come back as a result of coming off the venlafaxine. Hope someone can help. cheers.

1 like, 18 replies

18 Replies

  • Posted

    Hello Denise,

    My pleasure to respond. I think this is a good avenue to get some alternative views. On reading your note, it strikes me that a basic procedural mistake was made ( IMHO ). What I crave is stability, so introducing Mirtazapine should have been the only change. Once a stable result is achieved then another change could be contemplated. Given that your man was clearly suffering, I am puzzled that it was felt to be the right thing to reduce the dose of Venlaxine. David.

  • Posted

    Hi there,

    I'm currently taking venlafaxine 225mgs, mirtazapine 22.5mgs and 625mgs of lithium all for MDD and dysthymic disorder. Best combo ever. I've been on venlafaxine for 5 yrs before poop out. I did have slight serotonin syndrome from the combo but didn't get serotonin toxicity. A psychiatrist prescribed the lithium but my GP added the mirtazapine. He did however know that I would be consulting with my psychiatrist the following week. I was cranky at the shrink for not taking me off venlafaxine, but discontinuation scared her away from making any changes. But I was already having discontinuation via poop out. So my GP agreed to add the mirtazapine coz I was beside myself and not sleeping. The combo has settled down and I am not experiencing any serotonin excess. I did however reduce the lithium when it seemed I was having serotnin excess. I am lucky however as I have an anesthetist Int he family to consult with. Aside from my personal story here, I can suggest going slow anytime you're adding a medicine. And if ur worried about serotonin toxicity go to ur emergency. It's comon for some people to get serotonin toxicity on even a starting dose on ANY single antidepressant. The combo does kick some butt, so go easy. And remember serotonin syndrome is a spectral syndrome. It can be mild and go away or go the opposite direction and become dangerous. Ideally you have A psychiatrist making your medication recommendations with your approval.

  • Posted

    Hi! Just had to say I've been on venlafaxine/mirtazapine combination for several years now with no problems and it's really worked for me. When venlafaxine alone wasn't enough, iwas afraid that I'd have to withdraw from it & start again with something new. I was very relieved to be offered the combination which started helping quite quickly. It was prescribed by psychiatrist, GP not familiar with it,& some pharmacists query it.. CBT also great help & I'm now on an even keel. All the best Marcus.

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