Help interpret lab results: EBV Eval

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I have been battling chronic fatigue and lethargy for 4-5 years of my life now. I am only 21 years. I work full time as a certified clinical medical assistant. I have so many aspirations and goals, but my fatigue is becoming so debilitating that I don't know how I am going to be able to keep up with everything at this rate. Some of my other symptoms include ongoing low-grade fevers, malaise and arthralgia, rapid weight gain. My medical history includes history of PE due to unknown origin, iron deficiency anemia, elevated CRP, elevated ESR, positive lupus anticoagulant, and post axial polydactyly of upper and lower extremities bilateral. I've had numerous work-ups: sleep studies, allergy testing, genetic testing, hematology/oncology, rheumatology, thyroid work up with my PCP. So far, no answers. However, one test that stood out to my PCP was my EBV evaluation results as follows:

EBV Capsid, AG, IGG: >750 (normal reference range: 0.0-21.9)

EBV Capsid, AG, IGM: 95.0 (normal reference range: 0.0-43.9)

EBV Nuclear, AG, IGG: 208.0 (normal reference range: 0.0-21.9)

EBV Early (D) AG, IGG: 9.3 (normal reference range: 0.0-10.9)

Is anyone able to interpret these results? My rheumatologist recommends I pursue a referral to a Infectious Disease specialist next. Do you think this might be helpful? THANK YOU!

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  • Posted

    Hi Brayden,

    So sorry to hear about your tough time. I'm not writing because I have any explanation to your results unfortunately, I am not in the medical profession and have no idea. But I have been through glandular fever and it's horrible and really sympathise that you have been feeling poorly for so long, just wanted to let you know that and offer you some hope and reassurance today that you still can and will recover and get better.

    Vitamins and herbs are good, I'm sure you already know that. One thing which has helped me a lot over the years with my health and energy is a thing called Bowen Therapy. It's a very safe, natural therapy, not widely practiced in certain countries but really I can't speak highly enough of it. Worth looking into.

    Thinking of you and really hoping and believing things will get better for you soon.


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    • Posted

      Thank you so much for your helpful response. Thank you for sharing some helpful ideas as well.

      I follow up with my PCP later this week. It was recommended that I see an Infectious Disease specialist, but I'm not sure if and how helpful that might be? Any feedback? Thanks!

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    • Posted

      Hey Brayden,

      You're welcome and just so sorry you've had such a struggle. Yes for sure it can't do any harm to see any infectious diseass specialist, I don't really have any experience of them so not sure what help they could offer, but certainly no harm in trying.

      Your youth is very much in your favour brayden, so take hope from that today. Your body has taken a battering last few years it sounds like, but I really do still believe you can and will recover, without any doubt in my mind, so hang in there and remember God can heal!

      Take care and thinking of you


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    • Posted

      Referral for infectious disease has been cancelled. They said that there's not much they will be able to help with. It was such a struggle getting through my shift at work today. Every limb in my body so weak I could barely walk let alone keep my head up. Got to keep fighting!

      Any vitamins and/or herbs in particular you recommend?

      Thanks for your support Craig.


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  • Posted

    Immunoglobulin G (IgG), the most abundant type of antibody, is found in all body fluids and protects against bacterial and viral infections.(post-acute)

    Immunoglobulin M (IgM), which is found mainly in the blood and lymph fluid, is the first antibody to be made by the body to fight a new infection.(acute phase)

    If IgM is positive, you might be in the early stage or in the acute phase! so the active infection!

    If VCA-IgG e EA-D IgG are positive, probably you're infected by the EBV or you recently had an infection!

    If VCA-IgM is negative but you have VCA-IgG e EA-D IgG & EBNA positive, then you probably have had the infection in the past!

    I hope it's clear.

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  • Posted

    Healthcare providers can test for antibodies to the following EBV-associated antigens:

    Viral capsid antigen (VCA)

    Anti-VCA IgM appears early in EBV infection and usually disappears within 4 to 6 weeks.

    Anti-VCA IgG appears in the acute phase of EBV infection, peaks at 2 to 4 weeks after onset, declines slightly then persists for the rest of a person’s life.

    Early antigen (EA)

    Anti-EA IgG appears in the acute phase of illness and generally falls to undetectable levels after 3 to 6 months. In many people, detection of antibody to EA is a sign of active infection. However, 20% of healthy people may have antibodies against EA for years.

    EBV nuclear antigen (EBNA)

    Antibody to EBNA, determined by the standard immunofluorescent test, is not seen in the acute phase of EBV infection but slowly appears 2 to 4 months after onset of symptoms and persists for the rest of a person’s life.


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    • Posted

      HI Shyopi,

      EBV is the virus which causes mono / glandular fever, symptoms can be wide ranging but terrible fever, fatigue, malaise, gland pain can be included. Good thing is it's not as contagious as you would think, it's not transferred air-borne like a regular cold, it's passed through saliva so in that respect it's harder to catch. A simple blood test can tell though if the EBV virus is active in your system.

      This is a good forum for advice or encouragement, the good news is that despite it being a horrible thing to deal with, there is recovery and people do get better from it in the vast majority of cases.

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