Hemochromatosis and turmeric

Also of note in clinical studies, the iron levels was down but not detected in urine or feces. Meaning it wasn't carrying it out of the body.

yes , when dealing with all these supplements, you get excited one minute , then down the next. With regard to the Tumeric (curcumin) supplements, I was wondering IF once, chelated or inhibited, where the iron goes. Once absorbtion takes place -

First thought well if it goes into circulation, do you have to wait to be venesected ? or does it store elsewhere, as we know vital organs.

Second thought, does it come out of storage ready in waiting for venesection from our circulation.

I wonder how much iron load we can actually deal with in our circulation before it goes into the store and onto organs. If our bodies do the work from getting orders to the brain & cells from these supplements/inhibitors surely it must go into the waste, eg urine etc. at some point because we are trying to reeducate our cell brains to do so!!

Until I was diagnosed with HH My storage has gone to my liver causing cirrhosis, my storgae was 94% and levels 1975. Obviously my main question to the consultants was that I understood, only when my levels/storage comes down through weekly venesection will the storage start to be taken from my good bit of liver or at the very least not worsen as cirrhosis from iron overload is irreversible.

Going to the organs is kind of a last resort thing to do.  I think in most people there is a small amount of that, but for those of us with HH, it has potential to be much worse.

From the reading I had done, it does come out of storage in the organ as the serum levels go down.   The whole iron process & storage is complex, so I won't claim to fully understand it.  You do raise a question...what is the ferritin life cycle?  After a certain amount of time, does it just kind of die and become waste?  That is something I couldn't find. 

But the main answer is yes, it takes the load off of your liver.   Mine was inflamed when I started and now is not inflamed at all.  

I guess that is why frequent and regular venesections are important.  I feel terrible for those people when I read some people reporting that their dr says wait until their ferritin levels build up high again before having a venesection.  They have to educate themselve to educate their drs regarding appropriate treatment - or change drs.

People with hereditary haemochromatosis - their hepcidin does not turn on to turn off the absorption of iron.  It will not excrete.  Those without HH whose hepcidin works just do not absorb more iron than the body needs.  Of course there are always people with other problems, those with anaemia, thallisemia, and with high inflammation issues which have to be treated differently.

Try reading Prof Pierre Brissot (Rennes, France) for some light on the information you are seeking.