High igA in blood and bone density osteoporosis

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Can somebody explain how a high igA level in the blood can affect bone density and  cause ( or at least contribute to) osteoporosis?

I have been diagnosed with O.P. and my endocrinologist attributes it to  a high level of igA found in my blood ( 4.32).She has prescribed Resendronate once a week which I should start shortly.

Although I am an educated  person, I could not understand this link, even in the most general terms.. And , by the way, if somebody has any comment  or personal experience on Risendronate, I'd love to hear.  




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4 Replies

  • Posted

    Hi Ittiandro,

    I just had a Bone density test to determine if I had osteoporosis. I am not a doctor, so I have no idea how an IGA test alone could determine osteoporosis. I am curious to know how. You should ask your doctor to explain this. Best wishes to you!

    • Posted

      Thanks Brown45840

      Unfortunately, I do have osteoporosis because the bone density  scan  ( DXA) has yielded a T-score of -4.3 which is well below the threshold of o.p. ( -2.5) , just about as low as one can get!

      It is out of question that I have o.p.   even though I don't feel it and it doesn't restrict in any  manner my lifestyle and my sport activities! . 

      What I was saying is that the endocrinologist attributes it to an excess igA level detected by the blood test .

      She gave a rather cursory  explanation which I did not fully understand.

      I did not feel like discussing this any further.  She is a very well known physician and  a university professor and  we were both pressed for time ( I have been on her waiting list for eight months!).

      I think I should trust her. Just that I am very curious person! 

      Take care 


    • Posted

      Hi Ittiandro,

      Glad to hear that your osteoporosis is not hindering your life to much. I can sure understand why you would be curious about the IGA test. I am thinking maybe she saw your results of the bone density test and prescribed the resendronate. From what you wrote, I take she is a well qualified doctor. 

      Best wishes

  • Posted

    I have been using Actonel combi D in the form of a onc-a-month tablet of many years without any problems.

    Having been diagnosed with Non-Hodgkins Lymphoma, over 20 years ago, and having chemotherapy, mabThera and radiotherapy treatments, I was sent for a bone density scan which revealed that I am osteopaenic, hence I was started on the medication as a preventative for full-on osteoporosis.

    I didn't have a family history of bone problems, however it became evident that my readings were deteriorating after the cancer treatment, I have 20% compression fracture in my thoracic spine, and have had further spinal surgery, microdiscectomy due to nerve compression at L4 & L5 which caused debilitating sciatic problems.

    Surgery remedied the sciatic issues whereby I left my pain on the operating table, the thoracic issues are bearable at the moment.

    I hope that my experience with Actonel, little as it is, is of some kind of assistance to you.

    I'm interested to see what othershave to add.

    I wish you good luck in the future.


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