High MCV After 6 Yrs Of Treatment?

Posted , 2 users are following.

Hello, I hope everyone's as well as possible.

I was wondering whether anyone could help with a quick question at all..? I’m 30 and I’ve been treated with B12 injections every 3 months for the past 5-6years for Pernicious Anaemia. My MCV is still high (averaging 105). My doctor and rheumatologist were both clueless as to why it’s still like this on treatment. I was wondering if anyone had any thoughts; how long would these levels ordinarily take to drop back within normal range?

If you’re able to help at all that would be very much appreciated as I’ve nobody else to ask as the specialists don’t seem to know either.

Thank you so much! 😃


1 like, 1 reply


1 Reply

  • Posted

    Hi Caz,

    My MCV is also consistently at the top end and I've had P.A. for over 46 years

    It is also important that your Folate level is monitored as this is essential to process the B12.

    There is a complex interaction between folic acid, vitamin B12 and iron. A deficiency of one may be "masked" by excess of another so the three must always be in balance.

    Symptoms of a folate deficiency can include:

    *symptoms related to anaemia

    reduced sense of taste


    numbness and tingling in the feet and hands

    muscle weakness


    Folic acid works closely with vitamin B12 in making red blood cells and helps iron function properly in the body.

    I am not medically trained but personally I have taken 1 – Folic Acid 400μg tablet every day for more years than I can remember.

    I wish you well.

    Report Reply

Report as inappropriate

Thanks for your help!

We want the forums to be a useful resource for our users but it is important to remember that the forums are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the forums is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.