Histamine reaction when stopping omeprazole/prilosec

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has anyone else experienced a histamine when stopping a ppi? i tapered off it a month ago with minimal rebound, but since i began tapering i have been suffering with itching all over my body and a face rash has developed. i started it in october for a stomach ulcer which i think has now pretty much healed- still getting some digestive symptoms but nothing like what i was. just can't stop itching and can't get this rash under control!

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  • Posted

    I experienced a mild itching and rash when I started omeprazole. However, this reaction gradually subsided as I got used to the medication. This is a known side effect of the drug. I came off omeprazole cold turkey with no rebound and no itching or rash.

    Try coming off omeprazole completely first of all to see if the reactions subside but speak to your doctor if these reactions continue and ask for a topical cream to ease the itch and rash.

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    • Posted

      I have been off it completely now for a month- sorry that wasnt very clear from my op! and still itch and rash remain- dr is convinced theyre unrelated to omeprazole but seems too much of a coincidence seeing as both literally began overnight when i started the tapering process. I guess if its a symptom of the drug, it could also be a side effect of the withdrawal?

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  • Posted

    I have been cutting down my ppis and I have been noticing a lot more allergy rashes! I never put the 2 things together though. Try taking the tablets again and see if your rashes clear up, it is the only way to tell if that is what is causing it.

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    • Posted

      That's a good idea - although honestly i had such nasty side effects being on them (awful cramps, completely unable to digest any protein) that i'm super reluctant to go anywhere near them again!

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