How long can you live on anti-depressants before they wear out?

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I'm curious of how long you can take anti-depressants before they stop working. I was on Zoloft for 4 weeks and it made me much happier, but evenutally over time my anxiety and depression came back in the 5th week. My doctor has now put me on 100mg I was wondering if it will be the same cycle where it will work for a bit and then i'll have to continue increasing the dosage or that the particular dosage could possibly work best and I can continue using the same dosage for a long amount of time and it's still working. Because I seriously wouldn't mind taking a drug for life. 

If anyone could tell me their experinces it will be much appreicated. smile 

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