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Immunoglobulin and alternate pathway results ? Behcet's? Factor H deficiency

Posted , 5 users are following.

denae14404
denae14404

I'm hoping someone here has dealt with something similar to me. Last year I had acute bruising with several months history of infections and illness. I had blood tests which included my alternate pathway (AH50) and complement C3 and C4 tested. My AH50 was low at 40 (normal range 50-150) and C3 .1 within normal range and C4 .3 within normal range, both on lower aspect. Yesterday I had another blood test because I'm still constantly sick with different infections, mouth sores, colds/flu, serious coldness in hands and feet, not having more than 2 weeks break and I'm fed up! My immunoglobulin IgG was elevated above the normal range. So at least i know I'm not going crazy but I just don't know what I'm looking at here.

I already have autoimmune thyroiditis and have done for 10 years but have not had to deal with so much illness until last year.

Has anyone else had similar results? I've tried to do some research and looks like it could be a factor D or H deficiency or possibly Behcet's?

0 likes, 15 replies

15 Replies

  • margaret22116
    margaret22116 denae14404

    Posted

    hi, I have Behcet's. Not sure about your blood work. Others may have more expertise. The other symptoms yes are familiar to me. Do you get any genital ulcers?? Key to Behcet's. But also consider Lupus. Similar symptoms but without genital ulceration. 

     

  • margaret22116
    margaret22116 denae14404

    Posted

    also thyroiditis and vit d defficiency often go hand in hand with these systemic diseases. You need to see the right kind of specialist who will look at your whole disease profile and maybe consider a different diagnosis. Are you based in UK? 
    • denae14404
      denae14404 margaret22116

      Posted

      That's so much for your reply. I don't get genital ulcers at all so perhaps from

      Behcet's! Mostly just lots of sores in and around my mouth. Vitamin D and B12 are perfect. All general tests have been fine apart from thyroid every now and again. I only saw the GP to discuss the recurrent infections so you're right, time to see a specialist. I know my immune system isn't working the way it should be that's as far as we've got! Lot of the symptoms I get could be related to thyroid too so it's hard to determine. I've never been so sick in my life! It's taken over a lot, working in healthcare and carrying possible contagious germs, feeling too ill to exercise which is my favourite thing to do, sinus and chest infections, gastroenteritis, the list goes on! I'm awaiting an ANA (for lupus) at the moment so I don't know if it's that. I'm in Australia. Thank you for your help!

    • margaret22116
      margaret22116 denae14404

      Posted

      Yes consider Lupus more. The mouth sores can be a symptom of Lupus too. Sorry in a way to hear you are in Australia. Really bad for diagnosis and treatment as I understand it. Is there a Vasculitis support group there? If so a chat with them would help.
    • denae14404
      denae14404 margaret22116

      Posted

      It can be difficult here but very easy to get into see specialists and I work with a few physicians that specialise in complex medical conditions which is handy! We still seem way too far behind for medical treatments that the rest of the world. I'm sure there is a support group somewhere. I'll look into it. Thanks again!

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