Increased dosage with worrying side effects

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I have been on mirt for about three years after being diagnosed with PTSD. At the height of treating my condition I was taking 45mg but about a year ago reduced to 30mg. I do not recall any main side effects during these two periods of taking mirt. Unfortunately I have had a bit of a relapse and spoke with my GP who I creased the dosage back to 45mg. This increased dosage began two nights ago and I have only slept for about three hours in 48 hours, have increased anxiety to the point of suicidal thoughts and I can't afford to take another day of work tomorrow and need some urgent advice please......

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16 Replies

  • Posted

    Hi, I am currently withdrawing from mirt after 6 years usage. I can confirm what I have been advised from other users on here that this medication does seem to be more sedating at the lower doses i.e. at 30mg and below (i am currently down to 15mg and although sleep is sometimes difficult for me due to the wd, I am sometimes very tired during the day time). Having said that, I didn't have too many problems on the 45mg once I'd settled on it. Sometimes any side effects can take a week or two to settle down but if they're really troublesome it may be worth talking to your gp again.

    I hope you find some relief soon. Best wishes and take care. x

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  • Posted

     Go and see gp . You can't go on like this . You might be allergic to these.

    there are many other types to try. I have had mine changed as I felt so ill.

    good luck 

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  • Posted

    I had this on clomipramine. I am also on mirtazapine. I suffered severe agitation and intrusive suicidal thoughts. It can be due to the chemical changes in the brain and usuaLlysfaen does go away, but what is really important is doing what is best and safe for you. You must go back to your GO ASAP. Get an urgent appointment tomorrow. When you feel like this then you may have to go back to your normal dose. Please see your doctor tomorrow. 
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  • Posted

    Hi Tomo.

    I also felt like this for two weeks after increasing to 45mg. I felt very very depressed and questioned if the increase was a good idea. I'm just past the 2 week mark of increase and had my first good day since starting the tablets 7 week ago. The increase was worth it for me,even though the last 2 week where hell and I felt like id gone right back to square one.

    I think if you are worried then just go back to 30mg and speak to your doc as soon as possible xxx

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    • Posted

      Oh my sleep wasn't so great either for about a week but it soon went back to how it was. I sleep the same on each dose but I know others find the lower doses sedating. The thing I like better on the higher doses is that once they are in your system,that all day drowsiness doesn't happen xx
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  • Posted

    My mother had the same thing happen, and she just went back to the 30 mgs and waited for it to smooth out. If you are having suicidal thoughts, don't wait for anything, I don't know what you call your urgent care facilities, but I do know that you need to go there. The longer that you wait, losing sleep, the less you will be able to make rational choices about your health or personal safety. I don't mean to scare you, or maybe I do, mom overdosed on heart medication, and we almost lost her. She is fine now, but it to a while to get straightened out. Please, I don't know you, or where you are, but you need to get emergency care NOW! I worked for several years in our Emergency Room (not a doctor) and you need help. If you have friends or family, have one of them take you there as support, if not, call the ambulance service. Whatever you decide, you shouldn't be alone right now. David
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  • Posted

    David is right. You do need to see a doctor. If you can't tonight,  do you have anyone with you? Don't be alone. They are just thoughts,  but I know how awful thoughts are. There is always help out there out of hours if you need it. Excuse my typos earlier. Silly auto correct ☺
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  • Posted

    Actually reading some of these comments. Strange. When I was on 45mg I has manic highs and manic lows on a 7 day cycle. I do not have manic depression and never have, but the dose had to be dropped to 30mg because when I got the lows they were horrific. I had all sorts of suicidal thoughts.  I didn't act on them but they were terrifying. I didn't have a problem to start with on 45mg. It was 8 months in. I did seek help though when the thoughts started. It did stop once I reduced. I am still here and doing good. Things do get better, but so important you have support x
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  • Posted

    To follow up on Stardust, yes they are just thoughts, but the worse things that have ever happened in this world started out as "just thoughts". And your ability to keep them as "just thoughts" will slowly wither away if you aren't sleeping and getting nutrition. That is where the "batteries" in your body, the ones that give you willpower, get their power from. I am a Christian, and have asked God to watch over you while you get help. Please help Him to help you. I don't know you, but my heart goes out to you. Don't Be Alone!
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    • Posted

      I totally agree. When withdrawing off of seroxat a few years ago people said to me in response to the thoughts I was having were 'they're just thoughts " yes they were, but the power and horror of chemically induced thoughts or any intrusive thought is very distressing and real for that person. I've worked in mental health. I've been there myself and seen many others suffer the same and worse than myself.  There is always help out there 24/7. 
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    • Posted

      Excellent information, and very well put. Although we are trying to help someone who is having withdrawal issues with a specific drug, this information and advice can be helpful to anyone having withdrawal for any drug. You put it perfectly in that it is nothing less than horror to have a chemical (drug) that you have faith in helping you, given to you by someone who is paid to have your best interest in mind, now controlling your thoughts, emotions, and general sense of well being, and doing it in a very bad way. You never know; penicillin will cure one person while being fatal to someone who has an unknown allergy. Once again, it is no longer a matter of "do I take 30 mgs or 45", this person is way beyond that if she is willing to put on this forum that she is literally being tortured by her own mind, and that she has at least considered that death would be a relief.
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    • Posted

      I've never had intrusive or suicidal thoughts.....UNTIL chemical withdrawal from antidepressants. And an increase of antidepressants. Your brain is saying what the he'll is happening? ! And your mind is afraid of what is happening and what you are feeling. This is a time when patients need to be closely monitored. I do want to say though to Tomo apart from the obvious of getting immediate help, you will be okay. But keep safe and don't be alone while you feel like this. 
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    • Posted

      I thought that I was getting the flu, and the GI symptoms were so bad, I thought that I might have colon cancer. It was snowballing and all sorts of symptoms had me literally torn between what was going on. Then it hit me, I called my doctor and she listened to what I was going through and right away put me back on the Remeron, and within 2 days I was a different person. So Tomo, to quote stardust, if you get help, you will be alright. But again, don't mess around with this, your well being and quality of life is suffering, and only you can get the help that you obviously need.
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