Increased dose to 300mgs

Posted , 3 users are following.


I started venlafaxine 3 months ago and had been on 225mgs for 10 weeks. I noticed slight improvement but not enough to function normally. I lacked energy and motivation and still felt low. So pysch increased me to 300mgs a week ago. Since then I am totally exhausted, spaced out and really tensed. I feel like I’m really stressed physically like tense muscles in my neck/shoulders and feel irritable. Has anyone else felt worse on increasing or had any of these side effects? I’m worrying a lot. Thankyou 

0 likes, 4 replies

Report / Delete

4 Replies

  • Posted

    hello, i recently saw a pysc, and had my dose increased from 225mg to 300mg just over a week ago, after being on ven for almost 5 months. took higher dose for a couple of days, didnt like spaced out feeling, dropped to 262.5 mg. have felt better since. if i need to, i can go up to 300mg at a later date. with you being om ven for only 10 weeks, its not surprising you are more anxious. most people get more amxious for a few weeks after a dose increase. id always increased ven doses by 37.5mg since being on 150mg, and havent felt an increase in anxiety. if its unbearable, you could ask your pysc for a low level benzo to help, until the higher dose is working.
    Report / Delete Reply
  • Posted

    just to add. increases in ven of 75mg are a bit larger than going up a dose with other anti depressants. i think the spaced out feeling is the higher ben dose starting to work, in that it initially knumbs you. when it happens with me, usually leads to a positive result after a couple of weeks. a few weeks after going up to 225mg, for a whole week i felt rigid with tension, and thought id gone to high. lois on here said dont drop, as i was going to. i didnt, and after a week it passed and hasnt returned. both of your symptoms suggest the higher dose is starting to work, and shouldnt last more than a couple of weeks. if you are coming out of a deep depression, to come out of it fully, i think its inevitable that you have to go through these initial side effects.
    Report / Delete Reply

Join this discussion or start a new one?

New discussion Reply

Report or request deletion

Thanks for your help!

We want the forums to be a useful resource for our users but it is important to remember that the forums are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the forums is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.

newnav-down newnav-up