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Hello people. My husband has been on Mirtazapine 45mg at night for over three months for severe depression and anxiety. His sleep pattern has altered considerably. When he was on 7.5mg he slept a good 6-8 hours. Now he is on 45mg he sleeps 2-3 hours at the most and is awake from 2am onwards most mornings. He was assured the 45mg would knock him out, which clearly they don't. From your experience would splitting the dose to say 15mg at night and 30mg in the morning help?
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