Interaction from mirtazapine, magnesium glycinate, and effexor??

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So some back story is I've been dealing with depression and anxiety for years and was stable at one point but for the past two years it's been extremely terrible.

I was on mirtazapine 15mg, rexulti 1mg, and venlafaxine 37.5mg for a about 7 months. I was barely getting through even on all of those medications so my psychiatrist raised rexulti to 2 mg for about a month and I didn't like the way it made me feel. My psych then lowered rexulti back to 1mg and then took me off it completely. She switched me to wellbutrin 100mg which increased suicidal thoughts for me. I felt absolutely terrible. I was on it as well as the others for about two weeks. She took me off of wellbutrin and increased mirtazapine to 30 mg. The next day I took magnesium glycinate 100 mg hoping to get some relief from how bad I was feeling. So at this point I was on 30mg mirtazapine, 37.5mg venlafaxine and had just gotten off of wellbutrin a day or two prior to taking the magnesium glycinate. I'd also been taking fish oil on and off for months.

Shortly after taking magnesium glycinate, I noticed my breathing slowed a bit but wasn't too bad. The next day my chest was feeling tight like it was hard to take a deep breath and I had a weird pain in my throat with a lot of anxiety and some lightheadedness. This continued for a few days to a week. I got sick a couple days after with a cold or possibly my sinuses, (I'm not really sure what it was). It was hard to pin point what was causing what. I got off wellbutrin, then took mag glycinate, then started feeling all these different symptoms a day after then got sick a couple days after that. It was hard to tell if it was the mag glycinate or not especially since I didn't fully feel symptoms until the next day and I only took 1 dose of 100mg. The pains in my chest/throat eventually went away. I still feel lightheaded and have this weird cloudy feeling in my head, I'm very sensitive to noise, have headaches, and everything just feels like a dream. It's really scary. About a week after seeing some improvement in ny symptoms, my psychiatrist wanted me to add folate to my combo of mirt 30mg and venlafaxine 37.5mg, which I did. The cloudiness in my head increased so a week after I stopped the folate. That was a week ago. Since I took the mag glycinate and later the folate, I've been feeling lightheaded, extreme brain fog (which I had to a lesser extent before), bad memory (which was already failing before), headaches, noises seem so loud, bad anxiety, some restlessness, and it seems like I'm in a dream.

I'm worried that I messed up my brain from taking the magnesium glycinate with the mirt and venlafaxine combo and then worsened it by taking folate later. Will these symptoms ever go away? I'm absolutely terrified and even more so depressed over this. I wish I never took the magnesium glycinate sad

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  • Posted

    Hi kjcg44718

    We note from a recent post which you have made to our forum that you may be experiencing thoughts around self-harm. If we have misinterpreted your comments then we apologise for contacting you directly. But if you are having such thoughts then please note that you are not alone in this, and there are people out there that can help.

    If you are having these suicidal thoughts then we strongly recommend you speak to someone who may be able to help. The Samaritans offer a safe space where you can talk openly about what you are going through. They can help you explore your options, understand your problems better, or just be there to listen.

    Their contact details are on our patient information leaflet here: https://patient.info/health/dealing-with-suicidal-thoughts, which also offers lots of other advice on how you can access the help you may need.

    If you are having such thoughts then please do reach out to the team at the Samaritans (or the other people detailed in our leaflet) who will understand what you're going through and will be able to help.

    Kindest regards

    Patient

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  • Posted

    I recognise a lot of what you describe, from the flu-like symptoms to the brain fog and memory loss, but put it down to withdrawal and/or changes to antidepressant meds. In my case a combo of paroxetine, mirtazapine and amitriptyline. I think the mirtazapine was probably the worst. I'm now on a lowered dose of paroxetine plus the amitriptyline and contemplating how and when to reduce further. I find the short term memory problem very worrying. People keep trying to persuade me that it's only temporary but I'm sure it's been deteriorating for some years on these meds. Hope things improve for us both. Wishing you well.

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    • Posted

      Thanks so much for responding. I guess maybe it could be the combination of changing so many meds within a short amount of time, so thanks for helping me view it from that point of view. I took the magnesium glycinate and since it wasn't recommended by a doctor, I automatically assumed every symptom was related to that. I've been feeling these different symptoms for like 3 weeks now so I'm scared it will never go away. I feel like I'm going crazy and on the verge of a nervous breakdown. The feeling like im in a dream, the headaches, feeling spaced out, lightheadedness, and feeling like every noise is loud, all these symptoms are so troubling and freaking me out. Hoping all is well with you and that you'll be able to taper down your medications effectively without severe withdrawal symptoms.

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  • Posted

    Ps magnesium has also been suggested to me. I've been taking it in a multivitamin/ mineral tablet and Epsom salt baths. As antidepressant withdrawal can be a bit delayed it's easy to confuse with taking other things. Don't know if that seems possible to you? Just seems to be my experience. Xx

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  • Posted

    Have you come across survivingantidepressants website. Masses of info and supportive people who have all gone through similar problems. I think the best advice seems to be to try to stabilise on steady doses rather than to keep changing things. My GP gave me dramatic changes of meds and I'm sure it gave me huge problems which I am still trying to recover from. Keep posting. It's good to find a companion during this horrid trauma! Cx

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  • Posted

    Hello! I was also terrified by the intensity of the withdrawal symptoms. I didn't know what they were to start off with but have found so many similar stories that I'm sure that's what it is. With me it was almost complete insomnia and anxiety for weeks. Physically I had drenching sweats, muscle spasms and electric shock-like symptoms. It has left me traumatized and struggling with v low self confidence. I suppose I'm really rather badly depressed. I'm struggling through the days somehow and hoping things go on getting better. How are you now? Keep posting if you can. I think and hope sharing experiences helps. It was such a relief to me to find I'm not alone with these dreadful experiences. Xx

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    • Posted

      I'm sorry your withdrawal symptoms are so severe. You're right, speaking about it definitely helps to feel like we're not alone in this. My depression is pretty severe too. My symptoms are so different from the typical withdrawal symptoms that I'm not sure this is even withdrawal. Ugh so stressful! sad Hope you make it through. Are you planning to wean off all your meds?

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