1. Community
  2. Men's health
  3. Prostate Problems

Intra-prostatic injections?

Posted , 15 users are following.

Light1
Light1

Hi Guys,

Does anybody remember a year or so ago there was a discussion here about a newer treatment for BPH supposedly in clinical trials in the US but approved in some countries in Europe. It was an injection directly into the prostate that was said to result in significant shrinkage and clinical improvement in LUTS. Can anyone point me to the thread, or tell me the name of that product?

Thanks in advance for any help.

0 likes, 38 replies

38 Replies

Next
  • kenneth1955
    kenneth1955 Light1

    Posted

    Good morning

    As far as I know they are still working on it there are some trails but nothing has been approved yet.

    Fexapotide is one of the name that the injections is going by. There was a Phase 3 trail in February of 2018 trying to get it approve by the FDA but no luck yet.

    It would be very good for men with BPH problem. We will just have to wait and see.

    Have a good day.....Ken

    • Light1
      Light1 kenneth1955

      Posted

      Thank you, Ken. That's the exact one I was looking for!

      Hope you have a good day too,

      Fred

    • frank27027
      frank27027 kenneth1955

      Posted

      Hi Ken, I 'm back on the forum after a bad case of this infection C-diff. Don't ever take antibiotic Clindamicin, this antibiotic is nortorious for getting C-diff. Dentists usaully prescribe this for pain. Also i would like to send jimjames a PM ,do you know how i can do this?

      thanks

      frank,

    • iqbal_45667
      iqbal_45667 kenneth1955

      Posted

      Nice to know that some thing easier is being considered considered for this problem affecting most of us. Let us hope positive results come out soon.

    • kenneth1955
      kenneth1955 iqbal_45667

      Posted

      Yes it would be nice.

      We will just have to see what happens.

      Have a great day...Ken

  • arlowood
    arlowood Light1

    Posted

    HI there

    Was intrigued by your post and went delving online for info. The link below reports some of the most recent findings on Fexapotide.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348527/

    The results do seem encouraging but what was also a surprising finding reported at the end of the paper was that an injection of 10ml of sterile saline (as the placebo I believe) produced benefits equal to or better than treatments with alpha blockers or 5ARI inhibitors after 1 year. Beyond that time the benefits of Fexapotide started to become clearer and outperform other drug interventions.

    • Light1
      Light1 arlowood

      Posted

      Thank you! Interesting report.

      Best wishes,

      Fred

  • richp21
    richp21 Light1

    Posted

    Thanks for researching this. Definitely something to keep checking in about.

    • Light1
      Light1 richp21

      Posted

      Thanks. It would be great if this were approved and actually worked!

  • derek76
    derek76 Light1

    Posted

    Botox was being used at one time but not heard more about it recently.

    • Light1
      Light1 derek76

      Posted

      Yes, thanks. I thought that was interesting.

    • arlowood
      arlowood derek76

      Posted

      Just dug up another relatively recent paper on Botox and BPH

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780293/

      Early enthusiasim apopears to have waned due to some large randomised studies showing no difference between placebo and Botox treatment. However the author believes that there are subsets within the data that indicate that some groups did benefit from the Botox treatment.

      It's also interesting to note that the placebo (sterile saline) did have a positive and measurable benefit. This has been attributed to the placebo effect but perhaps there is more to it than that. In my previous post about Fexapotide the authors of that report also noted significant benefits from the sterile saline used as a placebo - these benefits lasting for at least 12 months.

      I'm just wondering if you can sustain a "placebo effect" for that length of time or is there some other hidden benefit from injecting sterile saline into the prostate that the researchers are overlooking.

      Just a thought - strangers things have happened in medicine before

    • derek76
      derek76 arlowood

      Posted

      Interesting conclusion and also that placebo gave a years relief.

      "In conclusion, use of BoNT-A on patients with LUTS secondary to BPH has been shown repeatedly to have a sustained effect to reduce prostate size and improve symptoms. Although large scale RCTs have not shown superiority to placebo, it may still have a place in specific groups of patients such as those who do not want to take long-term oral medications or patients who are poor surgical candidates."

  • Howard31850
    Howard31850 Light1

    Posted

    There have been 2 companies that have gone through Phase II and Phase III trials with direct injection into the prostate. The other one is Topsalysin which after one year did not show any statistical significance over the placebo. This was also the problem with Fexapotide though that company has been accused of tampering with the data. In both cases though the placebo effect was very strong and durable, lasting at least one year. This begs the question that why not just inject saline into the prostate and tell the patient it is a drug - this shows the power of the mind to heal the body!

    The third trials were with Botox injection but these were stopped because of 50% incontinence (temporary) with the same placebo effect.

    • Light1
      Light1 Howard31850

      Posted

      As usual, there's more to this than meets the eye. Thanks for the information!

      Best wishes,

      Fred

Back to top
Next

Report or request deletion

Thanks for your help!

We want the community to be a useful resource for our users but it is important to remember that the community are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the community is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.