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I know that many people are getting good results from using TNF alpha inhibitors, but are the long term effects a concern? Given that 80% of people diagnosed with AS were diagnosed before age 30, that is a long time to be on a immunosuppressive drug unless something better comes along. The first TNF blocker I think got on the market around 1999 and most of the others came shortly thereafter. So the longest time frame we are looking at is around 15 years.
What concerns me is the cumulative effect of taking these for 20, 30 or more years. I guess thats the nature of a new class of medication is you have about 2 years of clinical trials and then release it on the market and let the users give us the data as we go along.
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