is it safe to take certain recreational drugs on levothyroxine?

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does anyone have any experience of taking recreational drugs whilst on prescribed levothyroxine?

i know that ketamine reacts with levothyroxine -raising the heart rate and blood pressure. but all the information i can find and all the research that has been done is about the affects of levothyroxine with ketamine as an aesthetic that is injected (so therefor in a large amount at once)

however, there is no information about the results/risk of levothyroxine with smaller non injected amounts of ketamine done recreationally.

is it lethal and should drug users know about this?

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