ISTIN / Amlodopine misery...

Posted , 5 users are following.

I am looking to gather and share experiences of the drug Istin which is the brand name for Amlodipine.

I am a self-employed musician/guitar teacher in my mid-50's and have been on this horrendous drug for many years. Around 4 years ago I developed what I could only describe as a bad cold / hangover feeling with varying degrees of fatigue which slowly worsened until around 18 months ago when I started to feel absolutely terrible, some days almost unable to get out of bed.

Admittedly overweight and a bad snorer, I do exercise every day and I am a Vegan ( a diet I consider to be the most healthy and positively ethical choice these days).

After slowly and almost silently descending into what I would call premature old-age I was not myself, previously an outgoing, fun and upbeat guy had morphed into a depressive, negative, disinterested and irritable person. This situation had become so bad that I struggled to work and faced quitting my band of over 30 years!

Thanks to the wonderful NHS, I have had over the past 18 months MRI scans, counseling for depression and mindfulness , sleep tests, blood tests, have seen endocrinologists, respiratory specialists, neurologists and almost know the entire staff on first-name terms at St Georges in Tooting 😉

A couple of issues have been found, slight enlargement of Pituitary Gland and I do have Barrett's oesophagus, the latter I did not link to my symptoms of tiredness and inability to think straight.

The story is rather long and involved which has spiralled into often severe depression and feelings of total helplessness but I want to share this experience as FINALLY I have had a ray of light shine through the dark, gloomy cloud that has hovered above my head for so long.

After seeing several GP's at my local practice I recently saw a new doctor who seemed genuinely concerned at my situation which is not normal for a fairly healthy, young minded 50-something musician.

To my surprise and unlike any doctor I have ever met, she said, 'try coming off Istin for 10-12 days, check your blood-pressure regularly and come back to see me"

I am now two weeks off this drug and I have started to feel better, it is like a heavy, cold, dark, oppressive blanket has been lifted from my shoulders. I have more energy and am starting to laugh and joke once more. My blood pressure hasn't gone through the roof as I expected although I do keep an eye in it.

I am aware that psychological issues may be at work here, it could be all in my mind. I am still on edge waiting for the next problem or bad feeling to occur, I am not sure what will happen next BUT I hope my story may encourage people in a similar situation to address this problem.

After taking Amlodipine for many years with slight side-effects, it now strikes me that this drug can act negatively with ones body at different stages in life, or interact with new medications that have been introduced, it could be an interaction with Rivaroxoban, an anti coagulant medication I take that replaced the equally insidious Warfarin drug, I don't know.... all I do know is that after coming off Istin, I do FEEL BETTER!

It seems a mighty waste of time, money and resources that Health Professionals do not look into the side effects of drugs, maybe the millions of permutations of drug- interaction are impossible to analyse and, after all we are all different.

Thank God for our wonderful NHS and for sites such as this where we can share our experiences and hopefully, encourage others who are still suffering, often unnecessarily.

Feel free to write and share your thoughts.

Paul x

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7 Replies

  • Posted

    i have just started this medication three days ago. The first day i had a headache and too many trips to the loo to pee.

    The second and third day so far nothing. I am suppose to see my doctor in three weeks to review and decide if i want to continue taking this pill. I definitely prefer the natural way and that is my goal.

    I am almost 50 and was not ready to start medication. I am concerned about long term use and side effects. i hope that your health continues to improve. I agree that a vegan lifestyle is the best way to go

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  • Posted

    i feel this drug has ruined my life pulsating ears tired depressed bad nightmares stopping it and staying on atenolol and perindopril supose it works good for some people but in my case it was bringing my dialistic to low 18 months on it side affects started 3 months after starting it oh also have missed heartbeats now

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    • Posted

      oh wow i have been having serious second thoughts since i started this discussion. Too many times we suffer in silence when others can share their experiences in forums like this.how are you doing now?

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    • Posted

      i complety stopped 5 days ago feel so tired and heartbeat has tunrned into whoosing i was feeling fine before this drug diolistic is to low now still on perindopril

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  • Posted

    Who knows why !!!! If you think it maybe an interaction with another drug - well the question is, did the symptoms start soon after starting the other drug ?

    Please name all the GOOD endocrinologists in St Georges. Seriously, I'm looking at getting myself established as an NHS trust so I can choose my consultants from the whole pool !

    I've damaged my liver with painkillers - Aspirin/paracetamol - due to headaches. Bad bad headaches.

    I started Amlodipine for hypertension - and haven't had one of those headaches since. I know another person who has also found her headaches stopped when she started taking Amlodipine.

    I think the only real way to get answers is by trial and error. No one really knows !

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    • Posted

      Its funny that you mention this, I WAS GETTING A HEADACHE ALMOST DAILY. I HAVEN'T HAD ONE SINCE I STARTED THIS MEDICATION. I HAVE NEVER TAKEN ANY MEDS BEFORE SO IT'S DEFINITELY NOT an interaction. I KNOW FOR SURE ITS A REACTION FROM THE PILL. MY DOCTOR RECOMMENDED THAT I TAKE A HALF AT NIGHT AND HALF IN AM AS OPPOSED TO TAKING THE 10 MG AT ONCE. I HAVE DONE A LOT OF RESEARCH AND BASED ON WHAT I HAVE FOUND THEN COMPARING TO OTHER MEDICATIONS AND THEIR SIDE EFFECTS I AM DEFINITELY GOING TO GIVE IT A FAIR TRY AND TRY TO IMPROVE MY LIFESTYLE. MY BLOOD PRESSURE HAS DROPPED FROM 151/101 to 144/80 SO FAR. I AM AIMING FOR LOWER. MAYBE I WAS GETTING THE HEADACHES BECAUSE OF THE ELEVATED BLOOD PRESSURE. DUE TO MY FAMILY HISTORY I HAVE TO BE CAREFUL. MY DOCTOR ALSO SAID THAT THE SWELLING WILL MOST LIKELY GO AWAY AFTER A FEW WEEKS. MY RESEARCH SAID THE SAME. OVERALL I FEEL GREAT SO I AM GOING TO KEEP HOPE ALIVE.

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  • Posted

    HI paul - i was on Amlodipine for 5 years. It was an incredibly stressful period in my life coupled with also going thru menopause. To be quite honest, i never suspected that the amlodipine was the cause of most of my "issues" because the side effects didnt happen at first, they just crept up & kept coming & so i never put it together that it was the amlodpine causing my issues. Oddly enough, the amlodipine was not keeping my b/p down, so i got put on an additional drug, then at the 5 year mark the amlodipine got amped up to 10 ml from 5 - i was a walking zombie - Dr wanted to put me on another B/P RX - when i went to pick up the new B/P rX (to take in addition to the 2 others) the pharmacist told me the new B/P would raise my cholesterol. i thought why would i want to take a drug that would do that to me since my cholesterol was good. So, i came home and started researching all the side effects of B/P rX's and thats when i found this forum. i almost fell off my chair - 1. i had never thought to question my drs advice about an RX & 2. i realized all my symptoms were in fact legit & were not my imagination which is what my dr sort of made me believe. Everytime i complained about my symptoms she suggested i take anti anxiety Rx's & anti depression RX's. i immediately weaned myself off of the Amlodipine. It was not pretty. i felt awful for a long time, but things have improved...i can now literally get off the couch. i am on one blood pressure Rx, & i seem to tolerate it fine, my b/p is not ideal, but i can live with that, i couldnt live life with the amlodipine. Aside from all the nasty side effects, i also know that the amlodipine was the cause of my achilles tendoaphy. So now i have a deformity on both of my feet which makes long walks unbearable. i read that Calcium Channel Blockers can cause this, & since no one else in my family has this, i can thank amlodipine for this awful deformity - The drug that keeps on giving - it needs to be banned -

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