just been put on 37.5 mg of venlafaxine. Had immediate side effects of sickness shaking stiff legs

I'm taking them for servere mood disorder. And never had any antidepressants for years until lately. I was previously on citroplam I think that's the name not sure. But came off them after 3 days as side effects were so servere. I drive for a living and I'm dreading getting behind the wheel of this continues. In fact I won't be driving for a living if it does. I'm willing to keep at them but with work commitments etc I think it's gona be hard.

I'm also very irritable and feel like punching something, feel like screaming and feel very agrivated like I'm going to snap. Can't even hold a conversation with my partner without seeming angry. This feels worse not better. 😔

However you are reporting notable symptoms at start-up dosage on the first day which is really not justified and could point to other issues.

What symptoms did you have before being given medication? I mean how did your condition present?

Do you consume alcohol or take any other medication or supplements?

Have your doctors examined your overall health? 

Iv spoke to doctors today as I'm struggling. I assume they've taken everything in to consideration as I have fibromyalgia aswell. They've told me to take the full dose of 75mg on a night time and see how I do. I don't drink alcohol or take any other drugs or supplements at all. My symptoms before I got these tablets were suicidal thought's, sleeping all day, my brain goes so fast I couldn't focus or concentrate on anything for more than a few seconds. I was just shutting down. Hence the sleeping. Outbursts of anger and cursing, very irritated and lost my job, lost all of my confidence, Anxiety attacks, isolated myself from everyone, quite impulsive in my behaviour. One minute I'd be all smiles and the next I'd be vicious within a split second. Scared of everything, no motivation, nitemares, couldn't sit still for long. After I had had a episode of being energetic and cleaning washing all the stuff I needed to do in one go or a crying fit or an outburst of anger I'd just go straight to sleep and when I woke up I would feel great. It's a vicious cycle.

Please tell me you are being followed by a psychiatrist and not only GP? You have notable presenting symptoms. If you do not mind me asking, what happenned for you to escalate so, since as you say you have no prior history? Did it just come out of the blue or did some event or string of events trigger? Did you lose your job as a result of your escalating condition or was that a precursor to your escalation?

It is difficult to address your initial question given the intensity and mix of your symptoms.

What should, theoretically, come after adjustment issues is a very gradual but progressive smoothing out of your initial symptoms.

First the anxiety aspects should start lessening and along with them some mood lifting. I had rage problems in the second lap of my therapy (sudden outbursts) that took the longest time to resolve as they were caused by lingering anxiety and that took months to address. 

On 75mg, if this medication is right for you, initially you should feel calmer and more grounded. But you will have to wait and see until you adjust. The worst of adjustment disturbance takes a week or two. Adjustment is considered complete at the 6 week mark however.

If at any point you feel like you are escalating and find it difficult to control yourself, contact your doctor as you have correctly done now, or if it is really bad go to A&E immediately. 

I hope it does not come to this however and you start to respond to 75 more positively.

It didn't come out of the blue, iv had depression over the years for various reasons but never this intense. This is new to me. I lost my job due to what is occurring now. But I didn't identify it quick enough so ended up walking out on a bad day. Since then yes I'll admit it has got worse. Iv had family troubles etc but nothing out of the ordinary for me.

Yes I am being followed by a psychiatrist I was assessed and diagnosed with cyclothemia/servere mood disorder. But they won't give me anything else until I try venaflexin first as he thinks it's more depression. So depression route it is.

I have really servere anxiety at the moment worse than ever before. It makes me vomit.

The doctor has advised I take 75mg on a night instead of 37.5mg on a morning then 37.5mg on a night as I'm hoping to start a new job a week come Monday so can't be spaced out or have any vision problems for that. I suppose I will just have to wait and see how it goes. Thank you for your help I appreciate it.

Well...let's see how ven fares with your specific mix of symptoms. It did not do much for me initially for any similar symptoms. But in the final lap I saw improvement - I am assuming this happenned as a result of the lower layers of my condition finally being penetrated. This is how i rationalize it anyway. However, having said that, my condition was severe anxiety disorder that escalated to psychosis. My rage and outbursts were overload related (apparently). Plus there is a lot of learned behaviour as my father had serious rage issues (never went to doctor so never diagnosed or treated for anything)...

Anyway, I am looking forward to hearing you are doing better soon! This is what I wish for you.