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I've just been diagnosed with RA and prescribed Methotrexate, 10mgs to start, increasing to 20mgs over two weeks. I'm currently also on Prednisone (16mgs) as my GP thought it was PMR so I have to taper the Prednisone and wean myself off that. I took my first 10mg dose of Methotrexate Monday last but the pain seems to have gotten worse which I've read is common when starting on Methotrexate. The RA affects my wrists, forearms, elbows, upper arms and neck but the wrists are affected the most, I'm basically unable to use my hands without suffering severe pain, particularly late at night and in the mornings. Question: will the Methotrexate lessen the wrist pain and allow me to function or is the wrist pain going to be a permanent fixture? I've also noticed severe cramps in my trapezoid muscles when rising from rest, is this common?
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