I'm wondering if anyone has experienced anything similar to this situation. I was diagnosed with PMR in August 2016. It had come on rapidly and followed the common symptions. I was a very fit and muscular 64 yr old (woman) at the time. In the following 14 months the situation was fairly conventional: ie. if I took the right amount of prednisone I functioned normally. I had started at 25 mg. and at the 14 month point I was at about 10mg. Then, around this time I started getting pain in one shoulder and one knee, which in a couple of months morphed into both shoulders and both knees. Here, at approx. the 22 month point I still have two swollen and stiff knees and both shoulder joint area with soreness issues. The previous PMR soreness and stiffness issues in shoulder and hip girdle area is reduced to a minimal level, but now I'm limping around for a different reason. Knee Xrays show minimal arthritis. I'm thinking that it's the long term prednisone that might have caused the problem, through muscle wasting of the support structure around the knees. Since the prednisone did not seem to be helping to remove the issue in either my knees or shoulders I have worked my way off of it over the past couple of months. Any comments/ insight/suggestions would be appreciated.