Long-term effects of quetiapine

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Does anyone have any experience of quetiapine?  I'm not sure if it is working as well as it used to.

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6 Replies

  • Posted

    Hi Sharon,

    What is making you suspect that the Quetiapine is not working as well as it used to?

    What dosage are you on?  And, lastly what are you taking the med for?

    I have been taking SeraquelXR (long lasting, Quetiapine) 200 mg a day  & Quetiapine at night

    (up to 75 mg) to help with sleep.  I have bipolar disorder. Can't really say that I notice a change in the effectiveness over the 2 years I've been taking it.

    I do have some reservations in taking an anti-psychotic to enhance sleep. I was prescribed the medication initially for mania and the doctor has kept me on it.

    I wish you well and hope that you find answers.

    • Posted

      Thank you, Karin.

      I'm on 450mg daily plus 200mg of sertraline.  I was diagnosed with bipolar 2-3 years ago, although I have experienced more lows than high/manic periods.  It does help me sleep - which is great - but I am suffering more and more with periods of what I can only describe as agoraphobia.  Sometime I feel an 'electric' type twitch in my brain - nothing painful - just rather odd.

  • Posted

    Hi Sharon

    I was diagnosed with Bipolar 2 two years ago after years of being ill.Im 48 yrs old now! Iv had 2 very real manic stages but on the whole i suffer more low mood. For many years i was prescribed antidepresant after antidepresant and they made me worse. I found Sertraline did not agree with me at all. i felt physically and mentally

    awful and couldnt come off it quickly enough!

    I was then put on Quetiapine 300mg and the worst side effects have been weight gain and awful restless legs. To help with the restless legs the tablets were changed to modified release ones and i came down to 200mg. I now take 100mg in the morning and 100mg at night. I was quite tired at first but now my body is used to them this isnt too much of an issue. I also take 300mg of Pre-Gabalin for  anxiety. I do wish there wasnt the weight issue but for my Bipolar iv found Quetiapine to be a godsend. I hope it continues to work for me for as long as possible!!

    I hope iv been of some help to you.

    Take care




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