Long term use of Amlodipine

Posted , 29 users are following.

Hello

i have been using this drug for many years without problems, but recently I have begun to experience side effects which include swelling hands, ankles and calves.

aching legs and feeling very tired most of the time.

i am going to ask my GP if I can come off of this drug, I am interested in other  forum members experience with this perticular drug.

thanks

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  • Posted

    Most of the feedback on this forum is very negative about Amlodipine.  It's banned in the Netherlands and other European countries, and is licensed only for vetinary use - google it and see for yourself.

    One entry on this news group where reported very serious side effects, including peripheral neuropathy.  Another person was looking for people to join in a Class Action against the manufacturer.

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    • Posted

      YES, IT IS BANNED IN THE NETHERLANDS AND IN SEVERAL OTHER COUNTRIES FOR HUMAN USE. Their medical departments had weighed the negative side-effects vs the benefits, and the negative is definitely more.
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    • Posted

      Have to say I am alarmed to discover that it is banned in The Netherlands. I am from the UK but live in The Netherlands and  I was given it by my GP over here last year and have not felt right since but he won't change it. Time to find another GP I think.
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    • Posted

      It isn't actually banned in Holland, Dazzydog1976.  I chased down the regulator there and found out.  It just seems to be a medication that many people react to badly.  I wonder why it isn't |Yellow carded.  But my GP was quite protective about it.  'Not everyone has symptoms,' she said.  But I did and I'm off it now.  Anything that makes your ankles and feet swell prevent your legs acting like the ancilliary pumps they are...
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    • Posted

      Thanks Louise21984. I must admit I was surprised when I read that it was banned so I asked my wife whose father is a retired GP and he confirmed that it is banned. That said, I feel terrible on them and want to change GP in any case since this one doesn't listen to a word I say - and my Dutch isn't that bad! Thanks once again!
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    • Posted

      I hope you were able to get your amlodipine switched since your post.  I had to make up additional symptoms to get off of this sad

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  • Posted

    Take a look at my post. I had been on it long term, then a period of immobility from a knee cartilage op brought on swelling and side effects from which I have not recovered. A key indicator for me was a deep impression around the sock line
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    • Posted

      I had a deepening impression around the sock line. It is still there but it seems to be improving. Anything that makes you swell up and retain fluids cannot be beneficial!
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    • Posted

      Colibri, keep your socks off as much as you can while the fluid goes, also put your legs up if you can at rest.It will go I assure you, I found a slight bit of self massage helpfull to once a day on the ankle area helps somewhat.
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  • Posted

    Hi pc plod ... its  rare to have side effects of that kind after so long have you recently been put on a water tablet or a statin. i had youe symptoms from amlodipine but it was soon after taking them. wise to see your GP and see if you can get to the bottom of it.. Hope you get sorted soon. all the best.....len7
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  • Posted

    Pc Plod,

    After so long this sounds like something else has changed regarding your condtion. Clearly you bp needs attention and control in some form but not, IMO, with that awful drug. May I suggest you be persistant  with your gp and they should suggest an alternative.

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  • Posted

    Hi Everyone

    Many thanks for your responses.

    I am on atenonol and stations, always had slight swelling but nothing compared to now. Its also affecting my hands. Time to go back to the doctors.

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  • Posted

    What am I missing here.

    I do NOT get it.

    How could any human being use this drug for years with NO side effects?

    Then they just start years later?

    This does not sound right.

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    • Posted

      Hello Hitch,

      As a long time user of drugs (unfortunately and reluctantly) for an anxiety disorder and for blood pressure, I have had to change drugs a number of times when one failed to work as before, of when a particular brand of generic had particularly negative side effects.

      For example, Xanax (alprazolam) used to give me a nice euphoria for a while and calm my anxiety quickly. A wonder drug? As I have been changed to two different generics, it now gives me NO pleasant high (in fact, now a headache and unpleasant drowsiness, but it still stops panic attacks).

      Also, I used to eat tons of oranges and lemons, and now they're like pouring sulfuric acid into my blood. No change from name-brand to generic here, though.

      In answering your question, there are two factors that may be at work:

      1. The body changes, adapts, alters its response to the substance. In many cases, like my reaction to citrus, it begins to reject the substance (as if it gets tired of having to deal with it). Ask any allergist - overconsumption of any food runs the risk of becoming allergic to that very food. Also, the age of the consumer has a lot to do with how they react to medicines, as older metabolisms do not process things in the same way as younger bodies.

      2. The excipients (extra ingredients) in name-brand drugs and generic forms are often quite different. Most amlodipine (formerly Norvasc by US Pfizer) is generic now, most made by Lupin, a company in India, a country ridden with pollution and disease - I just watched a documentary on PBS that showed how the very water in India often carries an incurable bacteria (NDM-1). Although the main anti-hypertensive ingredient is still there, other different excipients (and water supply) may be used - and they may trigger negative reactions.

      I hope this clarifies the issue a bit for you. It is complex and may have various causes, but it is not at all unreasonable that side effects may occur years after starting a medication.

      I suppose that I was fortunate in that I began to experience negative side effects (perhaps to the basic amlodipine itself) only a couple of months after starting what I thought was the perfect answer to my blood pressure problems. The side effects apparently "took off" once it had reached a certain level of concentration in my body.

      Since it has such a long half-life (persistence in the body), I am still experiencing hot flashes, high BP spikes, racing pulse, etc. - things that never occurred before I took Lupin amlodipine - the Indian generic, which also concerns me.

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    • Posted

      Happened to me..been on 3 years and now experiencing calve swelling in both legs...have recently been taken off Amlod. But swelling continues...heard it might take 3 to 5 weeks to resolve. Have been checked for other isdues that might cause swelling..nothing else found.
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    • Posted

      Dear Colibri,

      Your description  "India, a country ridden with pollution and disease" smacks of ignorance and malice, There are so many medicines manufactured in India and other countries; why would only amlodipine produce negative side-effects? And why only in your country or the Netherlands. Try to help the members in the Forum with studied and researched facts not with irresponsible revelations like "  I just watched a documentary on PBS that showed how the very water in India often carries an incurable bacteria (NDM-1).

      Thanks.

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