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since using effexor xr for 3-4 months last year (while on a lean bulk), I noticed my gut starting to hang out a little and a lot of loose skin that I've never had in my life (despite being even 10 kilos heavier, always naturally lean, tight skin). chalked this down to 'weight gain' from the antidepressants, didn't think much more about it until 3-4 months later, coming off the medication due to illness, losing 7-8 kilos over the course of 6-8 weeks, and at the end of this (the leanest I've ever been at that weight), the loose watery skin remains sickeningly. also the gut issue which isn't a typical 'bloating' that comes and goes, it just distends 24/7. took me a while to connect the dots, but both of these bizarre phenomenons happened around the same time, so it cannot be a coincidence. I have ruled out fat given the above, the only two possibilities left are some kind of water retention (even with salt restriction doesn't improve), or else that the effexor has effected the firmness (collagen?) of the skin making it extremely loose and soggy, and also effecting the firmness of the organs or the fascia and connecting tissue holding them in place. I have been off the medication for 3.5 months now without any improvement. an ultrasound of the upper abdomen didn't show up anything suspect on the organs scanned. I am now leaning toward thinking the collagen or some other compound involved in keeping the skin/connective tissue/organs firm is responsible, although this is probably the worse outcome it makes a lot of sense, as both skin + gut issue I don't think it can rationally be a coincidence. if anyone has any advice on who to see or what to do that would be gladly appreciated, or anyone who may have similar experiences who wants to chime in
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