Low cholesterol diet and Prenisone pack effectively cured my two-year-old blepharitis

A friend killed her Blepharitis with a facial scrub with Benzethonium Chloride in it. They reformulated so I ended up using WET ONES, antibacterial hand wipes with Benzethonium Chloride in them and killed mine off too. They were wiped on the eyelash area not in the eye.

After killing it, a few were allergic to the lanolin and the Quats themselves so started to research why.

I found this info and also the antibiotic I think will kill it too.

Please let me know what you think. I am interested because of your science background.

Here it is:

 Staphylococcal blepharitis thought to be caused by a bacterium (germ) called staphylococcus.

Benzethonium Chloride (US) and Benzalkonium Chloride (UK) are Quats. These are the ingredients that are in the antibacterial hand wipes that kill Blepharitis.

Quats are effective in destroying a broad spectrum of harmful microorganisms. One is staphylococcus.

Quat-based disinfectants carry a positive charge. Bacteria, viruses and fungi carry a negative charge.

This results in the disruption of the bacteria cell wall and eventual death to the microbe.

However, even in the case of these relatively easy to kill pathogens quats often require a contact time upwards of 10 minutes to do so.

{I did not rinse the eyelashes after applying the antibacterial hand wipes.}

Bacteriostatic antibiotics

Bacteriostatic antibiotics limit the growth of bacteria by interfering with bacterial protein production, DNA replication, or other aspects of bacterial cellular metabolism. They must work together with the immune system to remove the microorganisms from the body. However, there is not always a precise distinction between them and bactericidal antibiotics; high concentrations of some bacteriostatic agents are also bactericidal, whereas low concentrations of some bacteriocidal agents are bacteriostatic.

Doxycycline is a broad-spectrum semisynthetic tetracycline.1 Doxycycline is bacteriostatic, inhibiting bacterial protein synthesis due to disruption of transfer RNA and messenger RNA at ribosomal sites.

Both of these (Doxycycline and the antibacterial hand wipes) work by disruption of the cell on contact. This is an article showing the dental application of Doxycycline. A topical application.

Dental Information

Please note: Anaerobic includes staphylococcus species

1In vitro testing has shown that Porphyromonas gingivalis, Prevotella intermedia, Campylobacter rectus, and Fusobacterium nucleatum, which are associated with periodontal disease, are susceptible to doxycycline at concentrations ≤ 6.0 µg/mL.2 A single-center, single-blind, randomized, clinical study in 45 subjects with periodontal disease demonstrated that a single treatment with ATRIDOX® resulted in the reduction in the numbers of P. gingivalis, P. intermedia, C. rectus, F. nucleatum, Bacteroides forsythus, and E. corrodens in subgingival plaque samples. Levels of aerobic and anaerobic bacteria were also reduced after treatment with ATRIDOX®. The clinical significance of these findings, however, is not known. During these studies, no overgrowth of opportunistic organisms such as Gram-negative bacilli and yeast were observed. However, as with other antibiotic preparations, ATRIDOX® therapy may result in the overgrowth of nonsusceptible organisms including fungi. (See PRECAUTIONS)

Pharmacokinetics

In a clinical pharmacokinetic study, subjects were randomized to receive either ATRIDOX® covered with Coe-Pak™ periodontal dressing (n=13), ATRIDOX® covered with Octyldent™ periodontal adhesive (n=13), or oral doxycycline (n=5) (according to package dosing instructions). The doxycycline release characteristics in gingival crevicular fluid (GCF), saliva, and serum were evaluated.

Doxycycline levels in GCF peaked (~1,500 µg/mL and ~2000 µg/mL for Coe-Pak™ and Octyldent™ groups, respectively) 2 hours following treatment with ATRIDOX®. These levels remained above 1000 µg/mL through 18 hours, at which time the levels began to decline gradually. However, local levels of doxycycline remained well above the minimum inhibitory concentration (MIC90) for periodontal pathogens (≤ 6.0 µg/mL)2 through Day 7. In contrast, subjects receiving oral doxycycline had peak GCF levels of ~2.5 µg/mL at 12 hours following the initial oral dosing with levels declining to ~0.2 µg/mL by Day 7. High variability was observed for doxycycline levels in GCF for both oral and ATRIDOX® treatment groups.

What I got from this is that Doxycycline applied topically reduced the anaerobic bacteria (Staphylococcus Species) just like the wipes did. It took several months but the wipes did kill the Staphylococcus. Antibiotics may take less time judging from the dental application of Doxycycline.

For those who cannot use the wipes, this may be something to look into. A chemist or Dr. would be the one to tell you the right amount for the eye.

These wipes did not go into the eye. This antibiotic would not go into the eye. Just put on the eyelashes to kill the Staphylococcus.

There may even be other antibiotics that are safe to put on the eyelashes that would kill Staphylococcus. A Dr. or chemist needs to be consulted.

 If this makes sense to you please let me know if you see what I see.

Lynda79

I was told I had high cholesterol after a routine fitness check about 5 years ago and reading your article I realise that the awful blephariits I currently suffer from also started aout that time.  I go 6-monthly to my local eye clinic but the only advice I have every had has been the usual hot pads and cleaning routine plus eye drops.  Your experience has really made me hopeful that this might be some clue towardys a cure.

Frankly, I have never taken the cholesterol warning very seriously as I am not overweight and thought I had a blanced diet.  the doctor just advised me to eat a Benecol yoghurt every day.  Do you have any hints for the diet.  I don't eat many fatty foods and don't own a frying pan.

I will go back to my doctor and discuss prednisone.

Thanks for info.

Rosie