Methotrexate

Posted , 9 users are following.

Hello all, I joined this group for my husband who has PMR. He was diagnosed about 14 months ago. Predinisone and other meds have not been successful to treat him so he was put on Methotrexate this week. Does anyone else here have experience with this med, good or bad? Thanks

0 likes, 40 replies

40 Replies

Prev
  • Posted

    Rose, I am also a 62 year old male.  Your husband's story touches me deeply. Praying for his improved health. 

    • Posted

      thank you. I have only been married to him for less than 3 yrs. I saw red flags of some serious health issues before we got married, but wrote it off as pre-wedding stress, etc. Aside from all of these health issues, he is a recovered alcoholic (sober since 1990) so I am worried he has liver damage from 2 decades of heavy drinking. I worry about him more than he worries about himself.
    • Posted

      How long did you court before you were married?  I was widowed twice had been married to wonderful men, whom I had known well before marraige.  Two years ago after 8 yrs. alone, i remarried after knowing him for only 8 months.  Not really long enough, but we are working on it.  Somestimes it can be very stressful.  I'm sorry you have to go through all of that, it isn't easy for you.

    • Posted

      we got engaged 5 weeks into dating, then married 9 months after our first date. Way too soon. But we had both been single a very long time and were lonely. Back then (this was 2013) he seemed healthy for the most part, but the normal aches that go along with middle-age. Then about 2 months prior to the wedding, his health started rapidly declining. I thought it was pre-wedding stress but now I see its the COPD, the PMR, etc etc. He has 4 health issues going on. The PMR seems to aggravate all the other conditions.
    • Posted

      "The PMR seems to aggravate all the other conditions."

      Or a vasculitis is aggravating all the others - and that might fit with the relatively sudden decline. I think you need to try to find a vasculitis specialist - are you in the UK?

    • Posted

      When we are dating and attracted to the gentleman, we seem to fail to see some of the so called negative attributes, not that we all don't have them!  If you really love or care deeply about him it's worth working on it.  Fortunately my husband is in super health.  He came from a different country where the "women follow the men"  So we're working on it.  Life is a challenge in so many ways, it does help us to grow.  My first husband had COPD and severe ashmatic bronchitis  and was very ill the last 2 yrs of his life, but very active before.  I understand whatit is like and wish you the best.  Elinor.

    • Posted

      Thank you for the reply. I appreciate it. Everyone on here has been so kind and caring
  • Posted

    Hi Rose

    I have PMR and was put on MTX just over a year ago in an effort to bring my pred dose down which I wasn't able to budge from 20mg! It works as a steriod 'sparer' and I was able to get down quite significantly over a few months to a more reasonable 10mg.

     

    My rhuemy has said on a few occassions *his* goal is to get me off pred, and I've recently (4 months ago) started on Actemra, a biologic usually prescribed for RA. It's further assisted me to reduce my pred dose and I'm currently on 4.5mg. of course *my* goal is to get to as low a dose as possible that controls the symptoms of PMR!

    I have a couple of questions though - if pred isn't working, then are you sure the diagnosis correct? If it's PMR then MTX won't help by itself. It just 'helps the pred work better'.

    What other meds has he tried, given pred is the only drug known to work effectively on PMR symptoms?

    Has he been told to wean off pred yet? What happens if (when) the sypmtoms return with a vengance?

    • Posted

      oh dear... the site must have been playing up again - not all of the responses showed up when I started replying. Looks like everyone else has sorted your questions out!
  • Posted

    I'm not going to comment on many of the isuues being discussed here! Suffice it to say I am an exception. I was put on methotrexate for my PMR because I refused to take preds. It took several weeks but it worked for me. I have been pain free for about a year now and returned to all my activities including league table tennis. I'm hoping soon to taper from my current dosage. And I have questioned my original PMR diagnosis - my specialist is still insisting it was correct.

    • Posted

      Might want to challenge that diagnosis. Methotrexate is often used to combat rheumatoid arthritis or a related inflammatory disease.  When MT works, it is often a sign of something other than PMR. That and the fact that you were able to live for weeks without prednisone, the only true "go to" for PMR leads me to suspect whether you should be convinced of your doctor's conviction. As we have seen, they are often wrong,

    • Posted

      funny you should say this, Daniel because I too have thought the dr doesnt really know whats wrong with him. The MT isnt working yet. He started it last week. 2nd dose is due tonight. Still having pain. But he wont stop going to the gym every day and exhausting himself there so he doesnt co-operate at all, not with me or his drs. I talked to my therapist, his GP and my religious advisor, they all suggested I wash my hands of this. Take care of him to the best of my ability but stop obsessing over him since he wont cooperate at all. I think he has something other than PMR as well. It might be RA, I dont know. He also has early dementia signs and COPD and heart failure. Yesterday he told me he knows he is winding down, all I can do is sit by and watch. He wont let me help. Thank you for responding. This has been a caring group of ppl
    • Posted

      Rose I am so sorry for all the stress you are going through. I am amazed that someone with PMR can go to the gym every day, I find I need a day to recover! I suppose it depends what he does when he is there of course. I think the advice you have been given is good, don't get stressed, if someone does not want to do something they will not listen to others giving advice. I do hope things get sorted out.

    • Posted

      I am amazed too. He uses up all his energy at the gym and comes home and crashes. Thank you for the reply
    • Posted

      MTX can take months to be seen to work whether it is in RA or PMR, although if it has done nothing after about 6 months they do usually reconsider. 
    • Posted

      Exactly my thoughts - at least 10-12 weeks. And it's not like you wake up and feel better.....more like a gradual improvement and the ability to reduce the pred, leading you to feel better.

Report or request deletion

Thanks for your help!

We want the community to be a useful resource for our users but it is important to remember that the community are not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in respect of any healthcare matters. Always speak to your doctor before acting and in cases of emergency seek appropriate medical assistance immediately. Use of the community is subject to our Terms of Use and Privacy Policy and steps will be taken to remove posts identified as being in breach of those terms.