Methotrexate and Sulfasalzine

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Anyone have any views or experience of taking Methotrexate and Sulfasalzine at the same time, the Rheumy has just added Methotrexate to my Sulfasalzine, just wondering if I should be worried, side affects etc, thanks.

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14 Replies

  • Posted

    I didn't notice anything. I wait until a symptom develops before reading side effects. I have such an active mind I would imagine having all of them!

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  • Posted

    I have taken both for nearly 2 years( diagnosed 2 yrs 3 months ago. I have been fine on both- no feeling sick, just some mild hair loss and feeling a bit of brain fog on the mxt day.

    But actually for  me a third dmard was added and then a biologic as didn't improve enough with 2 DMARDS ( mxt and sulfasalazine )

    2 DMARDS is a very standard approach to holding back the disease as it s been shown to be more effective than using 1. Many people find mxt really works for them. But some folks do have side effects which may or may not be got round- ( eg change time of dose/ pattern of folic acid/ ) so it s a case of try it and see how you get on. The monthly blood tests mean they monitor how you are. But the mxt takes up to 3 months to see if it works.

    Hope it works well for you.

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  • Posted

    Hi Veronica,

    I take bith, after I had to stop taking MTX plus Orencia due to infections from the Orencia. I was already on the mts for years, and adding the Sulasalazine has caused no problems. Mtx is stronger, and will probably take longer to get used to, it makde me very tired in the beginning--and that was a low dose orally-=and now I am on the maximum dose and inject it.

    Good luck. Stay in touch with your doc!


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    • Posted

      Thanks, I have been on Sulfasalazine for a long time but am having regular flare ups, so they are adding Methotrexate, they say I'll start with low dose orally if I'm ok with it I'll stay on it, if not I may get injections, I'm just a bit worried about side effects.

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  • Posted

    I have had no major problems with MTX, except getting used to it in the beginning. Lots of  fatigue, but now, I couldn't live without it. But am still looking gor much more help, as it's not enough.

    I now have Sjogrin's and some RA disease in my lungs, probably from so many upper respiratory infections while on  Orencia.

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