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Methotrexate dosage 2.5mg once weekly

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mable91367
mable91367

I will start taking Methotrexate 3 tablets (2.5mg) once per week.  My doctor told me to pick a day of the week.  So  I will start on Saturday.  I will also be taking folic acid (1 mg) on the alternate days.

This will be my 3rd medications.  So far, I have taken Azathioprine, Azulfidine and Leflunomide.  All of them made my stomach hurt, and Azulfidine made me vomit.

 I have a very sensitive stomach.  I was thinking about dividing the tablets up during the day on Saturday.  Maybe, like taking one tablet around 8am, and another tablet around 3pm and the last one around 10pm.  Do anyone take a divided dose in the same day? 

0 likes, 5 replies

5 Replies

  • patti85353
    patti85353 mable91367

    Posted

    My doctor told me I can do that too but I didnt need to on the 3 tabs, or 6 tabs, but now on the 8 tabs I do, it does help alot so try it and see. I started mine on Wed. so by the weekend I would feel ok, so you may want to re-consider taking on a weekend since the first 2 days are the worst as you increase. Good luck!
    • mable91367
      mable91367 patti85353

      Posted

      Thanks, Patti, how many pills did you start off with? I was doing it on the weekend because I am still working. You said that the first two days are the worst?

      My doctor don't want me to increase the dose. He just wants me to do the 3 pills weekly. I am also taking another drug by the name of Medrol on a daily basis. Medrol have completely stop all the pain but it is not helping with the inflammation.

      Sometimes I feel like this is too much drugs. My Mom wants me to go see another doctor for a second opinion.

    • patti85353
      patti85353 mable91367

      Posted

      I started with 2...no problems, went to 4, a little nauea and diarreah, then went to 8, not too fun but after 3 weeks I'm adjusting, until the next visit where they will double it again uugghh.
    • patti85353
      patti85353 mable91367

      Posted

      I started with 2...no problems, went to 4, a little nauea and diarreah, then went to 8, not too fun but after 3 weeks I'm adjusting, until the next visit where they will double it again uugghh.
    • mable91367
      mable91367 patti85353

      Posted

      Ok, so you started off with 2. Maybe I will take only 2 too the first time. As I mentioned I have a very sensitive stomach.
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