Methotrexate injections

Posted , 11 users are following.

Hiya everyone one I am a 25 year old female that has RA. I was just wodnering if anyone has the methotexate injections and if they get the side effects

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13 Replies

  • Posted

    3.5 years on MTX now and no side effects for me.

     

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  • Posted

    Hi there,

    I’ve been on methotrexate for a year, and moved to injections after 3 months approx. The tablets made me feel sick, but I’m fine on the injections - no sickness at all and I’m thrilled! I can tell my hair is thinning but that’s a small price to pay for having no pain and stalling the RA for future maintained mobility. No other side effects that I’ve noticed. 

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  • Posted

    Hi Kirsty

    Been on mtx for over 10 years now and again I get mouth ulcers but if you take folic acid it will help I take 30-40 mg weekly don't take the folic for 48 hours after the MTX as it will have little effect

    Big improvement on tablets as this by passes the digestive system

    With injections they may be able to keep the dose lower

    I go through periods of hair falling out but it regrow

    I am not on MTX only though I also take a monthly biological

    I was diagnosed 17 years ago

    I rule take folic acid it helps alot

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  • Posted

    Kirsty hi 

                 l was in the same boat as you, l was on tablet form for 4 months and was sick after every dose, l must of been losing the strength of the tablet dose which in turn showed up in my blood tests, l have just started the injections blood tests are better and thank goodness l am not getting sick anymore, good luck Kirsty

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  • Posted

    Hi kirsty I used to have the tablets but I had to stop them as I was affecting my liver hope you are OK on the injection x
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  • Posted

    I’ve had RA for only 2 years, been on methotrexate injections for about a year. I also take Hydroxychloroquine. On methotrexate tablets I had a lot of nausea and diarrhoea. Switching to injections fixed that and quite quickly reduced my RA symptoms until they are now almost completely gone. I still have occasional days of tiredness which may correspond to doses, or maybe it is still the disease. I really haven’t been able to determine, as fatigue was a really notable and early symptom for me.

    Now that I am able to, I have found very regular (daily) exercise really makes me feel better in lots of ways. 

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    • Posted

      Hi Blair. Just out of interest do you feel ok on Hydroxychloroquine? I had nausea and vomiting almost daily for the last 8 months I was on it even with anti sickness tabs. Consultant stopped it as I am on Methotrexate and a monthly biologic. Feel much better thank goodness.

      Elspeth

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    • Posted

      I don’t seem to have any issue with it. I have it at the same time as my evening meal, and have no issues with it.

      On the other hand about 5 months into treatment I also went onto a gradually building dose of sulfasalazine but had to drop that due to increasing nausea and finally the appearance of a pinprick rash on my feet/ankles lower calves. 

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  • Posted

    I am in the same boat as you, but have not started Methotrexate yet. Thanks for the info on the injections being better than pills. I think I will try that first. What has been others' experience with Hydroxychloroquine (Plaquel)? I tried that first and was nauseated by it, but I think its less liver toxic that Methotrexate. Has anyone out there tried biologicals and what was your experience with each drug you tried?

     

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    • Posted

      You will need to be patient and see how you actually respond. It took quite a few months for things to improve for me. I have seen advice that your tolerance can improve as your body adapts to the new stuff you’re putting through your system. It’s tricky to determine when you have had enough, and need to make a change. Keep talking to your specialist and doctor about your thoughts and concerns, they need to understand you so they can give you the information and support you need.
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  • Posted

    I have been on Methotrexate injury since 2009. Like everyone has said the tabs made me nauseous nearly all the time even with anti sickness tabs. My hair is thinning but missing just 1 injury causes problems. I started with mouth ulcers but now take my folic acid daily except the day of my injection. I take 25mgs weekly and also have a monthly biologic infusion. Hope this helps. Best wishes whatever you decide, Elspeth
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  • Posted

    Sorry Kirsty that should say injection not injury xxx 😀

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  • Posted

    Hi Kirsty, I have previously been on 20mg of MTX but had to stop because of liver damage. I have a weekly injection of Orencia biologic but recently been experiencing flares and as my liver blood results have improved my Rheumatologist has put me on a weekly injection of 7.5 MTX. Would you believe I never had problems on MTX tablets but experiencing nausea on the injections which is the opposite to everyone else. Hopefully you will follow everyone else and be nausea free. Keeping my fingers crossed for you. Mary
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