Methotrexate side effects- due to start soon

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I am due to to start this after my hols. Been on Steriods a month now and Been given more so i can enjoy my hols. Just wondering what side effects people suffer from methotrexate? I will be taking 10mg once a week first week of August. Dose will be increased gradually over the months.

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  • Posted

    Im at exactly the same stage and have been so well on the steroids am very nervous of starting methotrexate in August. Look forward to hearing peoples responses but do believe its such an individual thing.

     

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  • Posted

    Hi I have been on Mtx for 10 years now.  I was also dreading it but I’ve been fine.  The highest dose I’ve taken is 15mg and that did leave me feeling a little nauseous for a couple of days a week so they reduced the dose to 12.5 and changed me onto injections which are very easy and painless to do yourself and dealt with the nausea.  I know its daunting taking this drug but it does help with the RA, or at least it did with mine.  Good luck.
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    • Posted

      Hi

      How well does it keep your RA under control ? I am newly diagnosed and the Steriods have made a huge difference and worked quick. I was told methotrexate can take some time to take effect.

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    • Posted

      Yes it did help but I have Palindromic Arthritis and it wasn’t until they added in Hydroxychloriquine that it was fully under control.  To be honest, getting the drugs right varies from person to person.  What I would say is keep a diary and make a note of how you are feeling on a day to day basis.  I don’t tolerate co-codomol and ibuprofen well and it was through a diary that I worked that out. 
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    • Posted

      Thanks I am a bit apprehensive about methotrexate. My specialist assured me it's the best medicine for auto immune diseases and has been used since the 1950's And are the most widely used drug used to treat them.
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  • Posted

    My RA was pallindromic for a year or two, mostly feet, then knees, with the pain/flares  correlating with prolonged use/standing.  I was diagnosed after a more lengthy period of much pain and swelling, now in shoulder, hands, elbow, etc.  I cannot take steriods, and px NSAIDs helped a little in the beginning.  Soon thereafter, I took sulfasalazine for 3 weeks, then started on mex.  I have had only 2 doses of 15mg mex, with no side effects except great fatigue the following day.  But I have much fatigue anyway.  I recently started taking 2mg folate daily, and am hoping this wil combat the fatigue.  Overall, I have a bit less pain, but knees and especially hands are stiff and weak, even when not paining.  Perhaps the pain would have lessened without the meds?  I still have periods of fairly intense pain in some joint at least once per day, and pains still wake me during sleep.  I lwonder if there will ever be a time when I can forget, at leat temporarily, that I have RA.

    PS, my current, self- help regimen involves drinking lots of water and caloric restriction, and I eschew alcohol altogether.

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  • Posted

    hello michelle,

    i currently take 20mg of mtx and although the pain is less severe it is still there. it tends to differ from day to day. my main side effect is mouth ulcers, which i have constant and sometimes can be as apinful as the flares themselves. i do also have fatigue and am very stiff in the morning. hope it helps hun xx

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    • Posted

      My daughter is a pharmacist and she says methotrexate is the gold standard of the drugs for RA.  I started to read about all the side effects and stopped because I knew I couldn't live with the pain.

      i make sure I toss all the tablets to the back of my tongue and immediately swallow with as much water as I can drink.  Then I force myself to drink one or two glasses of water.  The one time I didn't drink a ton of water my throat was sore.  

      So so far the medicine has worked ok and the only notable side effect is thinning hair.

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  • Posted

    Hi

    reading about the possible side effects with all these drugs is off putting  but they explained  it was important to have a drug to hold back the progression of the disease  (DMARD ) ie methotrexate and not just have symptom relief ie steroid.

    I ve been taking methotrexate for 15 months now and don't have any nausea at all.  My dose went up to 25 mg over 3 months. It may have given me some brain fog, but I m not sure if that was a symptom of RAor methotrexate! It helps a lot of people. For me , other drugs have had to be added before I ve had a good level of relief but everyone is different. Also you tend to have to try methotrexate before other things are considered. It takes quite a few weeks before you can tell if it's helping. I kept a pain and disease progression diary saying if there were new joints affected, for that time and let my rheumy nurse know if it was still getting worse.

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  • Posted

    People respond very differently to MTX, so the best is to try it and see.

    I've been on it for 9 years. At first I had digestive problems from it and then injected (very easy with a fine diabetic needle). But now I take it orally, no side effects except some hair loss over time.

    It takes quite a few weeks to take effect, so be patient.

    Be sure to take folic acid during the week, a few days after the MTX (not at the same time). Your docs will have told you that, too.

    Don't worry. It's far better than the pain and possible disfigurement you would get from not taking it.

    Good luck!

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  • Posted

    Hello  Michelle I started Methatrexate like you gradually and now take 8 per week. At the beginning I felt fatigued but have had no other bad side effects. I was frightened at the beginning but now 5 years on realise they are used to slow RA down from progressing fast. 

    I wish you well and hope when it is in your system as it takes time you will get some releif

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  • Posted

    Hi Michelle. I have been on 25mg methotrexate in injection form for 6 weeks. I was diagnosed with ser negative arthriis 2 days before my 28th birthday in January. I started on 12.5 mg as my hands were so swollen and painful. Side effects were mainly tiredness and nausea but I combatted that with ginger tea and early nights. Methotrexate hasn't worked for me so I'm now on hydroxychloroquine as well at 400mg per day. I got up to max dose within 3 months. The side effects do reduce and whilst methotrexate hasn't worked for me yet it is a drug which can also work in conjunction with others. I've been told That I should be moved onto biologics within the next 4 months. Ive been monitored constantly since I've been on methotrexate and you get a lot of care from your rheumy team. 

     

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